Evoked Potentials, Saccadic Velocities, and Computerized Tomography in Diagnosis of Multiple Sclerosis

Overview

Journal Br Med J

Specialty General Medicine

Date 1977 May 21

PMID 861595

Citations 11

Authors

F L Mastaglia

J L Black

L A Cala

D W Collins

Affiliations

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Abstract

One hundred and two patients with suspected or established multiple sclerosis (MS) were investigated by one or more of the following techniques: measurement of visual evoked potentials (VEP); measurement of cervical and cortical somatosensory evoked potentials (SEP); measurement of horizontal saccadic eye movement velocities (SV); and computerised axial tomography of the cranium and orbits (CT). Each of the techniques was valuable in detecting abnormalities, some of which were subclinical, in many patients. More abnormalities were found in patients studied by more than one technique, the most being detected in patients who were studied by all five techniques. We conclude that the techniques have a complementary role in investigating suspected MS.

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Seland T Can Fam Physician. 2011; 30:1499-502.

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Correlation between spinal cord MRI and clinical features in patients with demyelinating disease.

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Effects of induced hyperthermia on visual evoked potentials and saccade parameters in normal subjects and multiple sclerosis patients.

Bajada S, Mastaglia F, Black J, Collins D J Neurol Neurosurg Psychiatry. 1980; 43(9):849-52.

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Nuclear magnetic resonance imaging of the orbit.

Moseley I, Mills C Br J Ophthalmol. 1983; 67(6):333-42.

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Evoked potentials in neurological diagnosis.

Mastaglia F, Carroll W Br Med J (Clin Res Ed). 1982; 285(6356):1678-9.

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References

Cala L, Mastaglia F . Computerised axial tomography in multiple sclerosis. Lancet. 1976; 1(7961):689. DOI: 10.1016/s0140-6736(76)92797-5. View

Mastaglia F, Black J, Collins D . Saccadic velocities in multiple sclerosis. Lancet. 1976; 2(7999):1359. DOI: 10.1016/s0140-6736(76)92012-2. View

McDonald W, Halliday A . Diagnosis and classification of multiple sclerosis. Br Med Bull. 1977; 33(1):4-9. View

Hennerici M, Wenzel D, Freund H . The comparison of small-size rectangle and checkerboard stimulation for the evaluation of delayed visual evoked responses in patients suspected of multiple sclerosis. Brain. 1977; 100 Pt 1:119-36. DOI: 10.1093/brain/100.1.119. View

Jestico J, Ellis P . Changes in nystagmus on raising body temperature in clinically suspected and proved multiple sclerosis. Br Med J. 1976; 2(6042):970-2. PMC: 1689261. DOI: 10.1136/bmj.2.6042.970. View

Bird A, Leech J . Internuclear ophthalmoplegia. An electro-oculographic study of peak angular saccadic velocities. Br J Ophthalmol. 1976; 60(9):645-51. PMC: 1042785. DOI: 10.1136/bjo.60.9.645. View

Gyldensted C . Computer tomography of the cerebrum in multiple sclerosis. Neuroradiology. 1976; 12(1):33-42. DOI: 10.1007/BF00344224. View

Mastaglia F, Black J, Collins D . Visual and spinal evoked potentials in diagnosis of multiple sclerosis. Br Med J. 1976; 2(6038):732. PMC: 1688817. DOI: 10.1136/bmj.2.6038.732. View

Halliday A, McDonald W, Mushin J . Delayed visual evoked response in optic neuritis. Lancet. 1972; 1(7758):982-5. DOI: 10.1016/s0140-6736(72)91155-5. View

10.

Robinson K, Rudge P . Auditory evoked responses in multiple sclerosis. Lancet. 1975; 1(7917):1164-6. DOI: 10.1016/s0140-6736(75)93138-4. View

11.

WILKINSON I . The influence of drugs and alcohol upon human eye movement. Proc R Soc Med. 1976; 69(7):479-80. PMC: 1864318. View

12.

Milner B, Regan D, HERON J . Differential diagnosis of multiple sclerosis by visual evoked potential recording. Brain. 1974; 97(4):755-72. DOI: 10.1093/brain/97.1.755. View

13.

Halliday A, McDonald W, Mushin J . Visual evoked response in diagnosis of multiple sclerosis. Br Med J. 1973; 4(5893):661-4. PMC: 1587677. DOI: 10.1136/bmj.4.5893.661. View

14.

RASMINSKY M . The effects of temperature on conduction in demyelinated single nerve fibers. Arch Neurol. 1973; 28(5):287-92. DOI: 10.1001/archneur.1973.00490230023001. View

15.

Gyldensted C . Computer tomography of the brain in multiple sclerosis. A radiological study of 110 patients with special reference to demonstration of cerebral plaques. Acta Neurol Scand. 1976; 53(5):386-9. DOI: 10.1111/j.1600-0404.1976.tb04356.x. View

16.

Kimura J . Electrically elicited blink reflex in diagnosis of multiple sclerosis. Review of 260 patients over a seven-year period. Brain. 1975; 98(3):413-26. DOI: 10.1093/brain/98.3.413. View

17.

Asselman P, Chadwick D, Marsden D . Visual evoked responses in the diagnosis and management of patients suspected of multiple sclerosis. Brain. 1975; 98(2):261-82. DOI: 10.1093/brain/98.2.261. View