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DNA Synthesis by Jejunal Mucosa in Responsive and Non-responsive Coeliac Disease

Overview
Journal Br Med J
Specialty General Medicine
Date 1977 Apr 30
PMID 861498
Citations 6
Authors
P E Jones
T J Peters
Affiliations
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Abstract

DNA synthesis by jejunal biopsy specimen from patients with coeliac disease and from controls was measured by an organ culture technique. The rate of synthesis in the mucosa of patients with untreated coeliac disease was almost eight times that in normal mucosa. Patients whose jejunal mucosa remained flat despite prolonged gluten withdrawal showed a rate of DNA synthesis significantly lower than that of the untreated patients, while those whose jejunal mucosa had responded to gluten withdrawal showed a rate similar to that of normal subjects. Impaired enterocyte production in nonresponsive coeliac disease may be responsible for the failure to regenerate villi after gluten withdrawal.

Citing Articles

Protein synthesis by cultured jejunal mucosa from control subjects and patients with coeliac disease.

Jones P, LHirondel C, Peters T Gut. 1981; 22(8):623-7.

PMID: 7286778 PMC: 1420058. DOI: 10.1136/gut.22.8.623.

Oral zinc supplements in non-responsive coeliac syndrome: effect on jejunal morphology, enterocyte production, and brush border disaccharidase activities.

Jones P, Peters T Gut. 1981; 22(3):194-8.

PMID: 7227852 PMC: 1419512. DOI: 10.1136/gut.22.3.194.

Alkaline phosphatase synthesis and properties of subcellular organelles during in vitro culture of jejunal biopsies from control subjects and patients with coeliac disease.

Jones P, LHirondel C, Peters T Gut. 1982; 23(2):108-14.

PMID: 7068034 PMC: 1419552. DOI: 10.1136/gut.23.2.108.

Biochemical studies of the isolated rat glomerulus and the effects of puromycin aminonucleoside administration.

Bhuyan U, Welbourn C, Evans D, Peters T Br J Exp Pathol. 1980; 61(1):69-75.

PMID: 6246912 PMC: 2041546.

Morphometric analysis of small intestinal mucosa. III. The quantitation of crypt epithelial volumes and lymphoid cell infiltrates, with reference to celiac sprue mucosae.

Marsh M, Hinde J Virchows Arch A Pathol Anat Histopathol. 1986; 409(1):11-22.

PMID: 3085335 DOI: 10.1007/BF00705403.

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