Prevention of Biofilm Formation by Polymer Modification

Overview

Journal J Ind Microbiol

Date 1995 Oct 1

PMID 8605077

Citations 25

Authors

B Jansen

W Kohnen

Affiliations

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Abstract

Bacterial biofilm formation on synthetic polymers plays an important role in industry and in modern medicine, leading, for example, to difficult-to-treat infections caused by colonized foreign bodies. Prevention of biofilm formation is a necessary step in the successful prophylaxis of such infections. One approach is to inhibit bacterial adherence by polymer surface modification. We have investigated polymer modification by glow discharge treatment in order to study the influence of the modified surface on bacterial adherence. Surface roughness, surface charge density and contact angles of the modified polymers were determined and related to the adherence of Staphylococcus epidermidis KH6. Although no influence of surface roughness and charge density on bacterial adherence was noticed, a correlation between the free enthalpy of adhesion (estimated from contact angle measurements) and adherence was observed. There seems to exist a certain minimum bacterial adherence, independent of the nature of the polymer surface. Modified polymers with negative surface charge allow for bacterial adherence close to the adherence minimum. These polymers could be improved further by the ionic bonding of silver ions to the surface. Such antimicrobial polymers are able to prevent bacterial colonization, which is a prerequisite for biofilm formation. It is suggested that modification of polymers and subsequent surface coupling of antimicrobials might be an effective approach for the prevention of bacterial biofilm formation.

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References

Ascher D, Shoupe B, Maybee D, Fischer G . Persistent catheter-related bacteremia: clearance with antibiotics and urokinase. J Pediatr Surg. 1993; 28(4):627-9. DOI: 10.1016/0022-3468(93)90675-b. View

Hampl J, Schierholz J, Jansen B, Aschoff A . In vitro and in vivo efficacy of a rifampin-loaded silicone catheter for the prevention of CSF shunt infections. Acta Neurochir (Wien). 1995; 133(3-4):147-52. DOI: 10.1007/BF01420065. View

Jansen B, Jansen S, Peters G, Pulverer G . In-vitro efficacy of a central venous catheter ('Hydrocath') loaded with teicoplanin to prevent bacterial colonization. J Hosp Infect. 1992; 22(2):93-107. DOI: 10.1016/0195-6701(92)90093-2. View

Costerton J, Khoury A, Ward K, Anwar H . Practical measures to control device-related bacterial infections. Int J Artif Organs. 1993; 16(11):765-70. View

Busscher H, Weerkamp A, van der Mei H, van Pelt A, de Jong H, Arends J . Measurement of the surface free energy of bacterial cell surfaces and its relevance for adhesion. Appl Environ Microbiol. 1984; 48(5):980-3. PMC: 241661. DOI: 10.1128/aem.48.5.980-983.1984. View

Ratner B . Plasma deposition for biomedical applications: a brief review. J Biomater Sci Polym Ed. 1992; 4(1):3-11. View

Khoury A, Lam K, Ellis B, Costerton J . Prevention and control of bacterial infections associated with medical devices. ASAIO J. 1992; 38(3):M174-8. DOI: 10.1097/00002480-199207000-00013. View

Marshall K, Stout R, Mitchell R . Selective sorption of bacteria from seawater. Can J Microbiol. 1971; 17(11):1413-6. DOI: 10.1139/m71-225. View

Jansen B, Kristinsson K, Jansen S, Peters G, Pulverer G . In-vitro efficacy of a central venous catheter complexed with iodine to prevent bacterial colonization. J Antimicrob Chemother. 1992; 30(2):135-9. DOI: 10.1093/jac/30.2.135. View

10.

Yasuda H, Gazicki M . Biomedical applications of plasma polymerization and plasma treatment of polymer surfaces. Biomaterials. 1982; 3(2):68-77. DOI: 10.1016/0142-9612(82)90036-9. View

11.

Liedberg H, Ekman P, Lundeberg T . Pseudomonas aeruginosa: adherence to and growth on different urinary catheter coatings. Int Urol Nephrol. 1990; 22(5):487-92. DOI: 10.1007/BF02549783. View

12.

Gerson D, Scheer D . Cell surface energy, contact angles and phase partition. III. Adhesion of bacterial cells to hydrophobic surfaces. Biochim Biophys Acta. 1980; 602(3):506-10. DOI: 10.1016/0005-2736(80)90329-6. View

13.

McLean R, Hussain A, Sayer M, Vincent P, Hughes D, Smith T . Antibacterial activity of multilayer silver-copper surface films on catheter material. Can J Microbiol. 1993; 39(9):895-9. DOI: 10.1139/m93-134. View

14.

Evans R, Holmes C . Effect of vancomycin hydrochloride on Staphylococcus epidermidis biofilm associated with silicone elastomer. Antimicrob Agents Chemother. 1987; 31(6):889-94. PMC: 284205. DOI: 10.1128/AAC.31.6.889. View

15.

Hoyle B, Jass J, Costerton J . The biofilm glycocalyx as a resistance factor. J Antimicrob Chemother. 1990; 26(1):1-5. DOI: 10.1093/jac/26.1.1. View

16.

Jansen B, Peters G . Modern strategies in the prevention of polymer-associated infections. J Hosp Infect. 1991; 19(2):83-8. DOI: 10.1016/0195-6701(91)90100-m. View

17.

Hoyle B, Costerton J . Bacterial resistance to antibiotics: the role of biofilms. Prog Drug Res. 1991; 37:91-105. DOI: 10.1007/978-3-0348-7139-6_2. View