Thromboembolism in a Patient with Transient Eosinophilia

Overview

Journal Ann Hematol

Specialty Hematology

Date 1996 Feb 1

PMID 8597615

Citations 3

Authors

H Y Mukai

H Ninomiya

S Mitsuhashi

Y Hasegawa

T Nagasawa

T Abe

Affiliations

Soon will be listed here.

Abstract

We report here a case of thromboembolism occurring in a 29-year-old woman with transient eosinophilia. Eosinophilia for at least 11 days was followed by pulmonary embolism. Both reperfusion of pulmonary arteries and disappearance of deep vein thrombi were obtained by treatment with urokinase, tissue plasminogen activator, and heparin. Although the causes of eosinophilia were not specified, we suggested a causative correlation of elevated serum levels of eosinophil granule proteins with the development of thromboembolism.

Citing Articles

Eosinophilia and first-line coagulation testing.

Lippi G, Montagnana M, Salvagno G, Franchini M, Targher G, Guidi G J Thromb Thrombolysis. 2008; 28(1):90-3.

PMID: 18618227 DOI: 10.1007/s11239-008-0247-5.

Cardiovascular manifestations of hypereosinophilic syndromes.

Ogbogu P, Rosing D, Horne 3rd M Immunol Allergy Clin North Am. 2007; 27(3):457-75.

PMID: 17868859 PMC: 2048688. DOI: 10.1016/j.iac.2007.07.001.

Hypereosinophilic syndrome with pulmonary and cardiac involvement in a patient with asthma.

Karnak D, Kayacan O, Beder S, Delibalta M CMAJ. 2003; 168(2):172-5.

PMID: 12538545 PMC: 140426.

References

Crofton J, Livingstone J, OSWALD N, ROBERTS A . Pulmonary eosinophilia. Thorax. 1952; 7(1):1-35. PMC: 1019138. DOI: 10.1136/thx.7.1.1. View

Takai K, Sanada M . Hypereosinophilic syndrome evolving to acute lymphoblastic leukemia. Int J Hematol. 1991; 54(3):231-9. View

Suenaga N, Hayashi F, Miyauhi N, Nakamura H, Kitada O, Sugita M . [A case of hypereosinophilic syndrome associated with pulmonary infarction and hepatic vein obstruction (Budd-Chiari syndrome)]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991; 29(2):239-44. View

Ratnoff O, Gleich G, Shurin S, Kazura J, Everson B, Embury P . Inhibition of the activation of hageman factor (factor XII) by eosinophils and eosinophilic constituents. Am J Hematol. 1993; 42(1):138-45. DOI: 10.1002/ajh.2830420127. View

LIEBOW A, CARRINGTON C . The eosinophilic pneumonias. Medicine (Baltimore). 1969; 48(4):251-85. DOI: 10.1097/00005792-196907000-00001. View

Esmon C, Owen W . Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci U S A. 1981; 78(4):2249-52. PMC: 319322. DOI: 10.1073/pnas.78.4.2249. View

Zafrani E, Farcet J, Mathieu D, Dhumeaux D . Hepatic vein obstruction in idiopathic hypereosinophilic syndrome. Arch Intern Med. 1985; 145(4):751-3. View

Weller P, Bubley G . The idiopathic hypereosinophilic syndrome. Blood. 1994; 83(10):2759-79. View

Griffin J, Evatt B, ZIMMERMAN T, Kleiss A, Wideman C . Deficiency of protein C in congenital thrombotic disease. J Clin Invest. 1981; 68(5):1370-3. PMC: 370934. DOI: 10.1172/jci110385. View

10.

Mukai H, Ninomiya H, Ohtani K, Nagasawa T, Abe T . Major basic protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia. Br J Haematol. 1995; 90(4):892-9. DOI: 10.1111/j.1365-2141.1995.tb05211.x. View

11.

REEDER W, Goodrich B . Pulmonary infiltration with eosinophilia (PIE syndrome). Ann Intern Med. 1952; 36(5):1217-40. DOI: 10.7326/0003-4819-36-5-1217. View

12.

Venge P, Dahl R, Hallgren R . Enhancement of factor XII dependent reactions by eosinophil cationic protein. Thromb Res. 1979; 14(4-5):641-9. DOI: 10.1016/0049-3848(79)90119-1. View

13.

Chusid M, Dale D, West B, Wolff S . The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore). 1975; 54(1):1-27. View

14.

Dahlback B, Carlsson M, Svensson P . Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A. 1993; 90(3):1004-8. PMC: 45799. DOI: 10.1073/pnas.90.3.1004. View

15.

Yamamoto H, Ninomiya H, Yoshimatsu K, Uchiyama Y, Shibasaki M, Enokihara H . Serum levels of major basic protein in patients with or without eosinophilia: measurement by enzyme-linked immunosorbent assay. Br J Haematol. 1994; 86(3):490-5. DOI: 10.1111/j.1365-2141.1994.tb04778.x. View

16.

Fauci A, Harley J, Roberts W, Ferrans V, Gralnick H, Bjornson B . NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med. 1982; 97(1):78-92. DOI: 10.7326/0003-4819-97-1-78. View