[Proton Magnetic Resonance of Plasma in the Evaluation of Systemic Effects of Cutaneous Inflammation in Rats]

NMR evaluation of skin rat inflammation, 24 h after UVB exposition and 48 h after vesicatory (croton oil) application, shows significant variations of relaxation times. Cutaneous T1 and T2 are enhanced in both cases, and plasmatic T2 is increased in croton oil inflammation. At the same time, these two inflammations induce in plasma: a significant increase in ceruloplasmin (respectively 70 and 42%); a decrease in iron transferrin (48 and 53%) and iron saturation (%) of transferrin (53 and 68%); an increase in the protein level of 45% for croton oil treated animals. In skin, for each inflammation, T1 is significantly correlated with cutaneous water content (r = 0.6 and r = 0.35). T1 appears to be more representative than T2 of hydration and molecular dynamic modifications, induce by oedema formation. In plasma, T2 is significantly correlated with ceruloplasmin (4 = 0.67) and protein level (r = 0.45), and reflects more specially than T1 the modifications of the medium composition. The decrease in T2 may be the expression of the diminution of the medium water molecules' mobility, in connection with the increase in protein concentration.