Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

Overview

Journal Science

Specialty Science

Date 1996 Mar 22

PMID 8596932

Citations 198

Authors

J P Ridge

E J Fuchs

P Matzinger

Affiliations

Soon will be listed here.

Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

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