Components of Energy Expenditure in the Mdx Mouse Model of Duchenne Muscular Dystrophy

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1996 Feb 1

PMID 8596695

Citations 7

Authors

A Mokhtarian

A Decrouy

A Chinet

P C Even

Affiliations

Soon will be listed here.

Abstract

Previous observations showing that basal heat production rates and glucose metabolism were reduced in mdx mouse skeletal muscles incubated in vitro led us to study the components of total energy expenditure by open-circuit indirect calorimetry in the intact, free-moving mdx mouse. Our purpose was to verify if the mdx mouse exhibited whole-body alterations in energy metabolism. The results revealed that total and basal energy expenditure, as well as spontaneous activity, energetic cost of activity, and, therefore, energy expended in relation to activity were not significantly different in C57B1/10 (control) and in dystrophic (mdx) mice. In contrast, the thermic effect of food was 32% larger in mdx than in control mice and was accompanied by significant differences in post-prandial glucose and lipid oxidation. The present in vivo study could not show a direct demonstration that impaired glucose metabolism by skeletal muscles participated in this phenomenon. However, since post-prandial glucose metabolism by skeletal muscles contributes a significant part of the thermic effect of food, the present data are in line with previous studies in vitro that show that mdx mouse skeletal muscles probably suffer an impaired control of their energy metabolism.

Citing Articles

Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in Mice.

Moore T, Lin A, Strumwasser A, Cory K, Whitney K, Ho T Front Physiol. 2020; 11:690.

PMID: 32636760 PMC: 7317021. DOI: 10.3389/fphys.2020.00690.

Dystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy.

Radley-Crabb H, Marini J, Sosa H, Castillo L, Grounds M, Fiorotto M PLoS One. 2014; 9(2):e89277.

PMID: 24586653 PMC: 3929705. DOI: 10.1371/journal.pone.0089277.

Practical aspects of estimating energy components in rodents.

van Klinken J, van den Berg S, Willems van Dijk K Front Physiol. 2013; 4:94.

PMID: 23641217 PMC: 3640188. DOI: 10.3389/fphys.2013.00094.

The different impact of a high fat diet on dystrophic mdx and control C57Bl/10 mice.

Radley-Crabb H, Fiorotto M, Grounds M PLoS Curr. 2011; 3:RRN1276.

PMID: 22094293 PMC: 3217191. DOI: 10.1371/currents.RRN1276.

Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome.

Griffin J, Des Rosiers C Genome Med. 2009; 1(3):32.

PMID: 19341503 PMC: 2664943. DOI: 10.1186/gm32.

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