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APC Gene: Database of Germline and Somatic Mutations in Human Tumors and Cell Lines

Overview
Journal Nucleic Acids Res
Publisher Oxford University Press
Specialty Biochemistry
Date 1996 Jan 1
PMID 8594558
Citations 81
Authors
C Beroud
T Soussi
Affiliations
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Abstract

A database is described in which over 700 mutations in the human APC gene of tumors (colon cancer predominantly) are compiled from the literature. It includes both molecular informations about the mutations and also clinical data about the patients. A software have been designed in order to analyse all these informations in the database.

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References
1.
Nagase H, Miyoshi Y, Horii A, Aoki T, Ogawa M, Utsunomiya J . Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res. 1992; 52(14):4055-7. View
2.
Su L, Johnson K, Smith K, Hill D, Vogelstein B, Kinzler K . Association between wild type and mutant APC gene products. Cancer Res. 1993; 53(12):2728-31. View
3.
Spirio L, Olschwang S, Groden J, Robertson M, Samowitz W, Joslyn G . Alleles of the APC gene: an attenuated form of familial polyposis. Cell. 1993; 75(5):951-7. DOI: 10.1016/0092-8674(93)90538-2. View
4.
Polakis P . Mutations in the APC gene and their implications for protein structure and function. Curr Opin Genet Dev. 1995; 5(1):66-71. DOI: 10.1016/s0959-437x(95)90055-1. View
5.
Nakamura Y . The role of the adenomatous polyposis coli (APC) gene in human cancers. Adv Cancer Res. 1993; 62:65-87. DOI: 10.1016/s0065-230x(08)60315-2. View