Comparison of Serum Calcitonin Levels After a 1-minute Calcium Injection and After Pentagastrin Injection in the Diagnosis of Medullary Thyroid Carcinoma

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 1977 May 1

PMID 858780

Citations 7

Authors

R K Rude

F R Singer

Affiliations

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Abstract

A 1-min calcium injection was compared with a pentagastrin injection as provocative measures in stimulating calcitonin secretion in 4 patients with medullary thyroid carcinoma. In all cases the calcium injection resulted in a greater rise in serum calcitonin concentration. The patients tolerated the calcium injection well. However, two patients experienced substernal pressure and dyspnea following the pentagastrin injection. It is concluded that a 1-min calcium injection is a safe, rapid and effective procedure in the diagnosis of medullary thyroid carcinoma.

Citing Articles

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Calcitonin stimulation tests for the early diagnosis and follow-up of patients with C cell disease: a descriptive analysis.

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Hypercalcitoninemia in thyroid conditions other than medullary thyroid carcinoma: a comparative analysis of calcium and pentagastrin stimulation of serum calcitonin.

Lorenz K, Elwerr M, Machens A, Abuazab M, Holzhausen H, Dralle H Langenbecks Arch Surg. 2013; 398(3):403-9.

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Medullary thyroid carcinoma: relationship of method of diagnosis to pathologic staging.

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