Botulinum-A Toxin As a Treatment of Detrusor-sphincter Dyssynergia: a Prospective Study in 24 Spinal Cord Injury Patients

Overview

Journal J Urol

Publisher Wolters Kluwer

Specialty Urology

Date 1996 Mar 1

PMID 8583552

Citations 49

Authors

B Schurch

D Hauri

B Rodic

A Curt

M Meyer

A B Rossier

Affiliations

Soon will be listed here.

Abstract

Purpose: The paralytic effect of botulinum-A toxin injections on the external urethral sphincter was investigated prospectively in patients with neurogenic voiding disorders.

Materials And Methods: Transurethral versus transperineal botulinum-A toxin injections were performed in 24 spinal cord injury male patients with detrusor-sphincter dyssynergia and the respective efficacy was compared.

Results: In 21 of 24 patients detrusor-sphincter dyssynergia was significantly improved with a concomitant decrease in post-void residual volumes in most cases. Botulinum-A toxin effects lasted 3 to 9 months, making reinjections necessary.

Conclusions: Although costly, botulinum-A toxin injections, which aim at suppressing detrusor-sphincter dyssynergia but not bladder neck dyssynergia, appear to be a valid alternative for patients who do not desire surgery or are unable to perform self-catheterization.

Citing Articles

An Alternative Approach for Treating Female Underactive Bladders with Chronic Urine Retention: A Pilot Study on Combined Transvaginal Ultrasound-Guided Botulinum Toxin A External Sphincter Injection and Transurethral Incision of the Bladder Neck.

Huang W, Tsai C, Chou E Toxins (Basel). 2024; 16(10).

PMID: 39453217 PMC: 11510944. DOI: 10.3390/toxins16100441.

Efficacy of Urethral Sphincter Botulinum Toxin A Injection in Patients with Spinal Cord Injury with Dysuria: A Retrospective Cohort Study.

Yu W, Tian J, Kuo H Toxins (Basel). 2024; 16(8).

PMID: 39195746 PMC: 11359143. DOI: 10.3390/toxins16080336.

Clinical Conditions Targeted by OnabotulinumtoxinA in Different Ways in Medicine.

Onan D, Farham F, Martelletti P Toxins (Basel). 2024; 16(7).

PMID: 39057949 PMC: 11280961. DOI: 10.3390/toxins16070309.

Onabotulinum toxin A improves neurogenic detrusor overactivity following spinal cord injury: a systematic review and meta-analysis.

Vaheb S, Mokary Y, Ghoshouni H, Mirmosayyeb O, Moases Ghaffary E, Shaygannejad V Spinal Cord. 2024; 62(6):285-294.

PMID: 38637637 DOI: 10.1038/s41393-024-00992-9.

The Efficacy and Safety of Intrasphincteric Botulinum Toxin-A Injections in Patients with Non-Spinal Cord Injury-Related Detrusor Sphincter Dyssynergia: A Retrospective Study.

Rothlin K, Anding R, Seifert H, Hund-Georgiadis M, Mohr S, Walter M Biomedicines. 2023; 11(11).

PMID: 38002018 PMC: 10669099. DOI: 10.3390/biomedicines11113016.