Geographical Clustering of Human T-cell Lymphotropic Virus Type 1 Infection in Honduras

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1995 Nov 1

PMID 8576361

Citations 5

Authors

I L de Rivera

L Amador

S Mourra

Z Li

S Rasheed

Affiliations

Soon will be listed here.

Abstract

Geographical clustering of human T-cell lymphotropic virus type 1 (HTLV-1) infection has been identified in the nonmestizo communities in several cities along the Atlantic coast of Honduras. Of the 2,651 serum samples tested, 122 samples were repeatedly reactive for HTLV-1 antibodies in two different enzyme immunoassays and 3 were indeterminate. These sera did not react in the HTLV-2-specific antibody tests. The presence of HTLV-1 antibodies was confirmed by HTLV-1 immunoblots or Western blots (immunoblots), and the infection was verified by the detection of HTLV-1-specific genetic sequences in the cellular DNA by PCR. Genomic DNA from the peripheral blood mononuclear cells was first tested with generic primers and probes that identified both HTLV-1 and HTLV-2. Next, all DNA samples that showed HTLV reactivity were tested by PCR with specific primers and probes that distinguished HTLV-1 sequences from those of HTLV-2. Our results indicate that only HTLV-1 infection was present in the blood of both mestizo and nonmestizo residents of 15 cities in the Republic of Honduras. The overall prevalence of HTLV-1 infection in the nonmestizo population was 8.1% (95% confidence limit, 6.6 to 9.7%). The mestizo population residing in the same geographical vicinities showed a HTLV-1 antibodies in 0.5% of serum samples tested (95% confidence limit, 0.6 to 1.7%), indicating a significantly greater prevalence of HTLV-1 infection in the nonmestizo population than in the mestizo ethnic groups living in Honduras (P = 0.0001). Since no HTLV-2 antibody reactivity or HTLV-2-specific genetic sequences were detected by PCR with different primers and probes, it was concluded that HTLV-2 infection was not present in the Honduran population groups we tested. Our study also suggested an endemic nature for this virus because there was no difference in the prevalence rate of HTLV-1 antibodies in the nonmestizo community living in the coastal towns of Honduras between 1989 and 1993. This is the first report of HTLV-1 cluster identification in Honduras, Central America.

Citing Articles

Clinical and Public Health Implications of Human T-Lymphotropic Virus Type 1 Infection.

Legrand N, McGregor S, Bull R, Bajis S, Valencia B, Ronnachit A Clin Microbiol Rev. 2022; 35(2):e0007821.

PMID: 35195446 PMC: 8941934. DOI: 10.1128/cmr.00078-21.

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED.

Chabay P, Lens D, Hassan R, Pinilla S, Gamboa F, Rivera I Cancers (Basel). 2020; 12(8).

PMID: 32759793 PMC: 7464376. DOI: 10.3390/cancers12082166.

A reliable Epstein-Barr Virus classification based on phylogenomic and population analyses.

Zanella L, Riquelme I, Buchegger K, Abanto M, Ili C, Brebi P Sci Rep. 2019; 9(1):9829.

PMID: 31285478 PMC: 6614506. DOI: 10.1038/s41598-019-45986-3.

Testing efficacy of teaching food safety and identifying variables that affect learning in a low-literacy population.

Mosby T, Romero A, Linares A, Challinor J, Day S, Caniza M J Cancer Educ. 2014; 30(1):100-7.

PMID: 24781933 DOI: 10.1007/s13187-014-0666-2.

Epidemiological Aspects and World Distribution of HTLV-1 Infection.

Gessain A, Cassar O Front Microbiol. 2012; 3:388.

PMID: 23162541 PMC: 3498738. DOI: 10.3389/fmicb.2012.00388.

References

Poiesz B, Ruscetti F, Gazdar A, Bunn P, Minna J, Gallo R . Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980; 77(12):7415-9. PMC: 350514. DOI: 10.1073/pnas.77.12.7415. View

Olaleye D, Ekweozor C, Sheng Z, Rasheed S . Evidence of serological cross-reactivities with human immunodeficiency virus types 1 and 2 and human T-lymphotropic virus types I and II in sera of pregnant women in Ibadan, Nigeria. Int J Epidemiol. 1995; 24(1):198-203. DOI: 10.1093/ije/24.1.198. View

Yoshida M, Seiki M, Yamaguchi K, Takatsuki K . Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A. 1984; 81(8):2534-7. PMC: 345097. DOI: 10.1073/pnas.81.8.2534. View

Gessain A, Barin F, Vernant J, Gout O, Maurs L, Calender A . Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985; 2(8452):407-10. DOI: 10.1016/s0140-6736(85)92734-5. View

Rosenblatt J, Golde D, Wachsman W, Giorgi J, Jacobs A, Schmidt G . A second isolate of HTLV-II associated with atypical hairy-cell leukemia. N Engl J Med. 1986; 315(6):372-7. DOI: 10.1056/NEJM198608073150606. View

Jacobson S, Raine C, MINGIOLI E, McFarlin D . Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis. Nature. 1988; 331(6156):540-3. DOI: 10.1038/331540a0. View

Lee H, Swanson P, Shorty V, Zack J, Rosenblatt J, Chen I . High rate of HTLV-II infection in seropositive i.v. drug abusers in New Orleans. Science. 1989; 244(4903):471-5. DOI: 10.1126/science.2655084. View

Ehrlich G, Glaser J, Lavigne K, Quan D, Mildvan D, Sninsky J . Prevalence of human T-cell leukemia/lymphoma virus (HTLV) type II infection among high-risk individuals: type-specific identification of HTLVs by polymerase chain reaction. Blood. 1989; 74(5):1658-64. View

Kwok S, Lipka J, McKinney N, Kellogg D, Poiesz B, Foung S . Low incidence of HTLV infections in random blood donors with indeterminate western blot patterns. Transfusion. 1990; 30(6):491-4. DOI: 10.1046/j.1537-2995.1990.30690333477.x. View

10.

Lairmore M, Jacobson S, Gracia F, De B, Castillo L, Larreategui M . Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama. Proc Natl Acad Sci U S A. 1990; 87(22):8840-4. PMC: 55055. DOI: 10.1073/pnas.87.22.8840. View

11.

Horal P, Hall W, Svennerholm B, Lycke J, Jeansson S, Rymo L . Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides. Proc Natl Acad Sci U S A. 1991; 88(13):5754-8. PMC: 51956. DOI: 10.1073/pnas.88.13.5754. View

12.

Lal R, Heneine W, Rudolph D, Present W, Hofhienz D, Hartley T . Synthetic peptide-based immunoassays for distinguishing between human T-cell lymphotropic virus type I and type II infections in seropositive individuals. J Clin Microbiol. 1991; 29(10):2253-8. PMC: 270308. DOI: 10.1128/jcm.29.10.2253-2258.1991. View

13.

Hjelle B, Appenzeller O, Mills R, Alexander S, Jahnke R, Ross G . Chronic neurodegenerative disease associated with HTLV-II infection. Lancet. 1992; 339(8794):645-6. DOI: 10.1016/0140-6736(92)90797-7. View

14.

Roberts C, Mitra R, Hyams K, Brodine S, Lal R . Serologic differentiation of human T lymphotropic virus type I from type II infection by synthetic peptide immunoassays. J Med Virol. 1992; 36(4):298-302. DOI: 10.1002/jmv.1890360412. View

15.

Maloney E, Biggar R, Neel J, Taylor M, Hahn B, Shaw G . Endemic human T cell lymphotropic virus type II infection among isolated Brazilian Amerindians. J Infect Dis. 1992; 166(1):100-7. DOI: 10.1093/infdis/166.1.100. View

16.

BENENSON A, Sepulveda-Amor J, Ascher M, Vugia D, Gallo D . Prevalence of human T cell lymphotropic virus types 1 and 2 (HTLV-1/2) in selected Tijuana subpopulations. Am J Trop Med Hyg. 1992; 47(2):127-32. DOI: 10.4269/ajtmh.1992.47.127. View

17.

Bernal J, Vaught D, Briceno I, Duran C, Yanagihara R, Gajdusek D . Coexistence of human T-lymphotropic virus types I and II among the Wayuu Indians from the Guajira Region of Colombia. AIDS Res Hum Retroviruses. 1992; 8(11):1851-5. DOI: 10.1089/aid.1992.8.1851. View

18.

Sanders R, Waiin P, Alexander S, LEVIN A, Blattner W, Alpers M . The prevalence of antibodies to human T-lymphotropic virus type I in different population groups in Papua New Guinea. Arch Virol. 1993; 130(3-4):327-34. DOI: 10.1007/BF01309664. View

19.

Bonis J, Baillou A, Barin F, Verdier M, Janvier B, Denis F . Discrimination between human T-cell lymphotropic virus type I and II (HTLV-I and HTLV-II) infections by using synthetic peptides representing an immunodominant region of the core protein (p19) of HTLV-I and HTLV-II. J Clin Microbiol. 1993; 31(6):1481-5. PMC: 265565. DOI: 10.1128/jcm.31.6.1481-1485.1993. View

20.

Moreira Jr E, Ribeiro T, Swanson P, Sampaio Filho C, Melo A, Brites C . Seroepidemiology of human T-cell lymphotropic virus type I/II in northeastern Brazil. J Acquir Immune Defic Syndr (1988). 1993; 6(8):959-63. View