Article: Prognostic value of p53 protein accumulation in cancer cell nuclei in adenocarcinoma of the uterine cervix

Adenocarcinoma of the uterine cervix (CxAd) is one of the most distressing malignancies of the female reproductive system because of its tendency to spread aggressively and to be resistant to radiation and systemic therapies. To clarify the prognostic significance of p53 alteration in CxAd, we immunohistochemically examined the incidence of p53 nuclear accumulation, which is considered to be mostly parallel with p53 gene mutation, and its association with clinicopathological parameters in 26 patients with CxAd. The overall incidence of p53 nuclear accumulation was 46% (12 of 26), being higher in groups with clinically advanced disease, higher degrees of cellular atypia, and deeper myometrial invasion, but significantly lower in patients with integration of human papillomavirus (HPV) type 16 or 18 DNA. Nuclear p53 immunoreactivity as well as lymph node status, depth of invasion and the absence of HPV-DNA integration were significant indicators of a poor prognosis. Examination of p53 nuclear accumulation could be applied to biopsy material, and would be of practical assistance in predicting the prognosis of CxAd both preoperatively and postoperatively.

Citing Articles

Immunophenotype and human papillomavirus status of serous adenocarcinoma of the uterine cervix.

Togami S, Sasajima Y, Kasamatsu T, Oda-Otomo R, Okada S, Ishikawa M Pathol Oncol Res. 2014; 21(2):487-94.

PMID: 25370301 DOI: 10.1007/s12253-014-9854-y.

References

1.

Kihana T, Tsuda H, Teshima S, Nomoto K, Tsugane S, Sonoda T . Prognostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix. Cancer. 1994; 73(1):148-53. DOI: 10.1002/1097-0142(19940101)73:1<148::aid-cncr2820730125>3.0.co;2-c. View

2.

Tsuda H, Hirohashi S . Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes. Jpn J Cancer Res. 1992; 83(11):1184-91. PMC: 5918705. DOI: 10.1111/j.1349-7006.1992.tb02743.x. View

3.

Kihana T, Tsuda H, Teshima S, Okada S, Matsuura S, Hirohashi S . High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy. Jpn J Cancer Res. 1992; 83(9):978-84. PMC: 5918982. DOI: 10.1111/j.1349-7006.1992.tb02010.x. View

4.

Peto R, Pike M, Armitage P, Breslow N, Cox D, Howard S . Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977; 35(1):1-39. PMC: 2025310. DOI: 10.1038/bjc.1977.1. View

5.

Tsuda H, Hirohashi S . Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer. Int J Cancer. 1994; 57(4):498-503. DOI: 10.1002/ijc.2910570410. View

6.

Hopkins M, Morley G . A comparison of adenocarcinoma and squamous cell carcinoma of the cervix. Obstet Gynecol. 1991; 77(6):912-7. View

7.

Jiko K, Tsuda H, Sato S, Hirohashi S . Pathogenetic significance of p53 and c-Ki-ras gene mutations and human papillomavirus DNA integration in adenocarcinoma of the uterine cervix and uterine isthmus. Int J Cancer. 1994; 59(5):601-6. DOI: 10.1002/ijc.2910590505. View

8.

Riou G, Favre M, Jeannel D, Bourhis J, Le Doussal V, Orth G . Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA. Lancet. 1990; 335(8699):1171-4. DOI: 10.1016/0140-6736(90)92693-c. View

9.

Iwaya K, Tsuda H, Hiraide H, Tamaki K, TAMAKUMA S, Fukutomi T . Nuclear p53 immunoreaction associated with poor prognosis of breast cancer. Jpn J Cancer Res. 1991; 82(7):835-40. PMC: 5918538. DOI: 10.1111/j.1349-7006.1991.tb02710.x. View

10.

Bodner S, Minna J, Jensen S, DAmico D, Carbone D, Mitsudomi T . Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation. Oncogene. 1992; 7(4):743-9. View

11.

Tinga D, Bouma J, Aalders J . Patients with squamous cell versus adeno(squamous) carcinoma of the cervix, what factors determine the prognosis?. Int J Gynecol Cancer. 1992; 2(2):83-91. DOI: 10.1046/j.1525-1438.1992.02020083.x. View

Prognostic Value of P53 Protein Accumulation in Cancer Cell Nuclei in Adenocarcinoma of the Uterine Cervix