The Source and Action of Histamine in the Isolated Guinea-pig Gallbladder

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 1995 Oct 1

PMID 8564521

Citations 4

Authors

L J Jennings

G M Salido

M J Pozo

J S Davison

K A Sharkey

R W Lea

J Singh

Affiliations

Soon will be listed here.

Abstract

We have investigated the effects of histamine on motility of the gallbladder and characterized the receptor types involved. Histamine and the histamine H1-receptor agonist, 2-thiazolylethylamine (2-TEA) contracted the isolated guinea-pig gallbladder strip in a dose dependent manner. The contractile response to histamine was shifted to the right by the H1-receptor antagonist, mepyramine. In pre-contracted gallbladder strips, the H2-receptor agonist dimaprit reduced the tension generated in a dose dependent fashion. The histamine H2-receptor antagonist, ranitidine shifted the histamine concentration effect curve to the left and attenuated the dose dependent relaxations elicited at high concentrations. The histamine H3-receptor agonist, (R)-alpha-methylhistamine (RMHA) elicited dose dependent contraction of the tissue which was significantly inhibited in the presence of mepyramine. The effects of electrical field stimulation (EFS) on the strips were not significantly altered by the presence of RMHA (10(-10) - 10(-7) M) indicating little pre-synaptic H3 activity in this tissue. Histamine immunoreactivity (IR) was detected in gallbladder whole mount preparations of the mucosa and the muscularis/serosa. The histamine IR appeared cell bound in cells of varying morphological characteristics but no IR was detected in nerve fibres or cell bodies (ganglia). Alcian blue staining was consistent with the distribution of histamine IR cells as mast cells. The results indicate that histamine is distributed in the guinea-pig gallbladder and it can regulate contractile activity via activation of H1 and H2 but not H3 receptors.

Citing Articles

Smooth muscle cells, interstitial cells and neurons in the gallbladder (GB): Functional syncytium of electrical rhythmicity and GB motility (Review).

Ding F, Hu Q, Wang Y, Jiang M, Cui Z, Guo R Int J Mol Med. 2023; 51(4).

PMID: 36928163 PMC: 10035990. DOI: 10.3892/ijmm.2023.5236.

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia.

Friesen C, Neilan N, Daniel J, Radford K, Schurman J, Li D BMC Res Notes. 2011; 4:322.

PMID: 21896203 PMC: 3224507. DOI: 10.1186/1756-0500-4-322.

Effect of Fructus Psoraleae on motility of gallbladder isolated smooth muscle strips from guinea pigs.

Jin S, Li M, Lin M, Ding Y, Qu S, Li W World J Gastroenterol. 2006; 12(32):5214-8.

PMID: 16937536 PMC: 4088023. DOI: 10.3748/wjg.v12.i32.5214.

Smooth muscle function and dysfunction in gallbladder disease.

Portincasa P, Di Ciaula A, Vanberge-Henegouwen G Curr Gastroenterol Rep. 2004; 6(2):151-62.

PMID: 15191695 DOI: 10.1007/s11894-004-0043-0.

References

Mawe G . Intracellular recording from neurones of the guinea-pig gall-bladder. J Physiol. 1990; 429:323-38. PMC: 1181702. DOI: 10.1113/jphysiol.1990.sp018259. View

Impicciatore M . Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ. Br J Pharmacol. 1978; 64(2):219-22. PMC: 1668321. DOI: 10.1111/j.1476-5381.1978.tb17292.x. View

Lorenz W, Matejka E, SCHMAL A, Seidel W, Reimann H, Uhlig R . A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals. Comp Gen Pharmacol. 1973; 4(15):229-50. DOI: 10.1016/0010-4035(73)90004-9. View

Black J, Duncan W, Durant C, Ganellin C, Parsons E . Definition and antagonism of histamine H 2 -receptors. Nature. 1972; 236(5347):385-90. DOI: 10.1038/236385a0. View

Hakanson R, Wahlestedt C, Westlin L, Vallgren S, Sundler F . Neuronal histamine in the gut wall releasable by gastrin and cholecystokinin. Neurosci Lett. 1983; 42(3):305-10. DOI: 10.1016/0304-3940(83)90279-3. View

Berthoud H, Jedrzejewska A, Powley T . Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with dil injected into the dorsal vagal complex in the rat. J Comp Neurol. 1990; 301(1):65-79. DOI: 10.1002/cne.903010107. View

Lennon F, Feeley T, Clanachan A, Scott G . Effects of histamine receptor stimulation on diseased gallbladder and cystic duct. Gastroenterology. 1984; 87(2):257-62. View

Arrang J, Garbarg M, Schwartz J . Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature. 1983; 302(5911):832-7. DOI: 10.1038/302832a0. View

Frieling T, Cooke H, Wood J . Histamine receptors on submucous neurons in guinea pig colon. Am J Physiol. 1993; 264(1 Pt 1):G74-80. DOI: 10.1152/ajpgi.1993.264.1.G74. View

10.

Ekblad E, Wahlestedt C, Hakanson R, Sundler F, Watanabe T, Wada H . Is histamine a neurotransmitter in the gut? Evidence from histidine decarboxylase immunocytochemistry. Acta Physiol Scand. 1985; 123(2):225-7. DOI: 10.1111/j.1748-1716.1985.tb07582.x. View

11.

Tamura K, Palmer J, Wood J . Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia. Neuroscience. 1988; 25(1):171-9. DOI: 10.1016/0306-4522(88)90016-4. View

12.

Wood J . Histamine signals in enteric neuroimmune interactions. Ann N Y Acad Sci. 1992; 664:275-83. DOI: 10.1111/j.1749-6632.1992.tb39767.x. View

13.

Bauer H . [The gallbladder as stress organ. A contribution to the pathogenesis of post-traumatic cholecystitis]. Chirurg. 1984; 55(12):828-9. View

14.

Thornell E, Jansson R, Svanvik J . Indomethacin intravenously--a new way for effective relief of biliary pain: a double-blind study in man. Surgery. 1981; 90(3):468-72. View

15.

Barnes P, Ichinose M . H3 receptors in airways. Trends Pharmacol Sci. 1989; 10(7):264. DOI: 10.1016/0165-6147(89)90024-2. View

16.

Lorenz W, Schauer A, Heitland S, Calvoer R, Werle E . Biochemical and histochemical studies on the distribution of histamine in the digestive tract of man, dog and other mammals. Naunyn Schmiedebergs Arch Pharmakol. 1969; 265(1):81-100. DOI: 10.1007/BF01417211. View

17.

Mack A, TODD J . A study of human gall bladder muscle in vitro. Gut. 1968; 9(5):546-9. PMC: 1552784. DOI: 10.1136/gut.9.5.546. View

18.

Waldman D, Zfass A, Makhlouf G . Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle. Gastroenterology. 1977; 72(5 Pt 1):932-6. View

19.

Mawe G . Noradrenaline as a presynaptic inhibitory neurotransmitter in ganglia of the guinea-pig gall-bladder. J Physiol. 1993; 461:387-402. PMC: 1175263. DOI: 10.1113/jphysiol.1993.sp019519. View

20.

Mawe G, Gokin A, WELLS D . Actions of cholecystokinin and norepinephrine on vagal inputs to ganglion cells in guinea pig gallbladder. Am J Physiol. 1994; 267(6 Pt 1):G1146-51. DOI: 10.1152/ajpgi.1994.267.6.G1146. View