Effect of Motilin on the Lower Esophageal Sphincter of the Opossum

Overview

Journal Am J Dig Dis

Specialty Gastroenterology

Date 1977 May 1

PMID 855853

Citations 2

Authors

J G Gutierrez

K D Thanik

W Y Chey

H Yajima

Affiliations

Soon will be listed here.

Abstract

We have studied the effect of Yajima's synthetic motilin on the lower esophageal sphincter (LES) of the opossum and compared its potency to that of gastrin and its interaction with secretin. Dose-response curves for the LES were constructed from the intravenous bolus injection of graded doses of motilin and gastrin alone and motilin given against a background infusion of secretin. The smallest dose of motilin that elicited a significant response was 0.05 microng/kg, and the highest response was observed with the highest dose used in this study (1.0 microng/kg). Over a wide dose range, both motilin and gastrin were found to be equally potent in stimulating the LES of the opposum, and secretin caused inhibition of the LES pressure to motilin. Therefore, we conclude that (1) motilin is a potent stimulant of the LES; (2) this response is dose dependent; (3) motilin's potency is similar to that of gastrin; and (4) secretin counteracts the effect of motilin on the LES.

Citing Articles

Radioimmunoassay of motilin. Validation and studies on the relationship between plasma motilin and interdigestive myoelectric activity of the duodenum of dog.

Lee K, Chey W, Tai H, Yajima H Am J Dig Dis. 1978; 23(9):789-95.

PMID: 707450 DOI: 10.1007/BF01079787.

Motilin: spectrum and mode of gastrointestinal actions.

Domschke W Am J Dig Dis. 1977; 22(5):454-91.

PMID: 324268 DOI: 10.1007/BF01071895.

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