An in Vitro Technique for the Rapid Determination of Drug Entry into Breast Milk

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1995 Oct 1

PMID 8554935

Citations 8

Authors

L J Notarianni

D Belk

S A Aird

P N Bennett

Affiliations

Soon will be listed here.

Abstract

1. A simple in vitro technique that predicts drug transfer into breast milk is described. 2. Drugs of differing physical and chemical characteristics were tested. 3. The technique provides an experimental system for studying plasma to milk transfer with changing milk composition. 4. A mechanism proposing a role of milk proteins in controlling drug entry into milk is discussed.

Citing Articles

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Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically-based pharmacokinetic model.

Abduljalil K, Pansari A, Ning J, Jamei M CPT Pharmacometrics Syst Pharmacol. 2021; 10(8):878-889.

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Prediction of Drug Transfer into Milk Considering Breast Cancer Resistance Protein (BCRP)-Mediated Transport.

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Development of an in vitro cell culture model to study milk to plasma ratios of therapeutic drugs.

Athavale M, Maitra A, Patel S, Bhate V, Toddywalla V Indian J Pharmacol. 2013; 45(4):325-9.

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[Course and treatment of myasthenia gravis during pregnancy].

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