Phospholipase C Delta 1 Requires a Pleckstrin Homology Domain for Interaction with the Plasma Membrane

Overview

Journal Biochem J

Specialty Biochemistry

Date 1995 Dec 15

PMID 8554502

Citations 24

Authors

H F PATERSON

J W Savopoulos

O Perisic

R Cheung

M V Ellis

R L Williams

M Katan

Affiliations

Soon will be listed here.

Abstract

The structural requirements of phospholipase C delta 1 for interaction with the plasma membrane were analysed by immunofluorescence after microinjection into living cells. Microinjection of deletion mutants revealed that the region required for membrane attachment and binding of inositol 1,4,5-trisphosphate in vitro corresponded to the pleckstrin homology domain, a structural module described in more than 90 proteins.

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