Structural Variation of the Pseudoautosomal Region Between and Within Inbred Mouse Strains

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1996 Jan 9

PMID 8552598

Citations 16

Authors

D Kipling

H E Wilson

E J Thomson

M Lee

J Perry

S Palmer

A Ashworth

H J Cooke

Affiliations

Soon will be listed here.

Abstract

The pseudoautosomal region (PAR) is a segment of shared homology between the sex chromosomes. Here we report additional probes for this region of the mouse genome. Genetic and fluorescence in situ hybridization analyses indicate that one probe, PAR-4, hybridizes to the pseudoautosomal telomere and a minor locus at the telomere of chromosome 9 and that a PCR assay based on the PAR-4 sequence amplifies only the pseudoautosomal locus (DXYHgu1). The region detected by PAR-4 is structurally unstable; it shows polymorphism both between mouse strains and between animals of the same inbred strain, which implies an unusually high mutation rate. Variation occurs in the region adjacent to a (TTAGGG)n array. Two pseudoautosomal probes can also hybridize to the distal telomeres of chromosomes 9 and 13, and all three telomeres contain DXYMov15. The similarity between these telomeres may reflect ancestral telomere-telomere exchange.

Citing Articles

Ensuring meiotic DNA break formation in the mouse pseudoautosomal region.

Acquaviva L, Boekhout M, Karasu M, Brick K, Pratto F, Li T Nature. 2020; 582(7812):426-431.

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Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.

Maxeiner S, Benseler F, Krasteva-Christ G, Brose N, Sudhof T Mol Biol Evol. 2020; 37(5):1243-1258.

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Instability of the Pseudoautosomal Boundary in House Mice.

Morgan A, Bell T, Crowley J, Pardo-Manuel de Villena F Genetics. 2019; 212(2):469-487.

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Meiotic Consequences of Genetic Divergence Across the Murine Pseudoautosomal Region.

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PMID: 28100589 PMC: 5340325. DOI: 10.1534/genetics.116.189092.

Sex chromosome recombination failure, apoptosis, and fertility in male mice.

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