Persistence of Serum and Salivary Antibody Responses After Oral Immunization with a Bacterial Protein Antigen Genetically Linked to the A2/B Subunits of Cholera Toxin

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1996 Feb 1

PMID 8550224

Citations 16

Authors

G Hajishengallis

S M Michalek

M W Russell

Affiliations

Soon will be listed here.

Abstract

Primary oral immunization of mice with a bacterial protein antigen genetically coupled to the A2 and B subunits of cholera toxin induced specific secretory immunoglobulin A and serum immunoglobulin G antibodies that persisted at substantial levels for at least 11 months. A subsequent single booster immunization did not further enhance the antibody responses. Long-term antibody persistence may be especially important in infections caused by common pathogens for which continuous immunity would be advantageous.

Citing Articles

Immunogenicity of a West Nile virus DIII-cholera toxin A2/B chimera after intranasal delivery.

Tinker J, Yan J, Knippel R, Panayiotou P, Cornell K Toxins (Basel). 2014; 6(4):1397-418.

PMID: 24759174 PMC: 4014742. DOI: 10.3390/toxins6041397.

Identification and characterization of intestinal antigen-presenting cells involved in uptake and processing of a nontoxic recombinant chimeric mucosal immunogen based on cholera toxin using imaging flow cytometry.

Zhao W, Minderman H, Russell M Clin Vaccine Immunol. 2013; 21(1):74-84.

PMID: 24197893 PMC: 3910925. DOI: 10.1128/CVI.00452-13.

Mucosal immunization with a Staphylococcus aureus IsdA-cholera toxin A2/B chimera induces antigen-specific Th2-type responses in mice.

Arlian B, Tinker J Clin Vaccine Immunol. 2011; 18(9):1543-51.

PMID: 21734065 PMC: 3165230. DOI: 10.1128/CVI.05146-11.

Induction and recall of immune memory by mucosal immunization with a non-toxic recombinant enterotoxin-based chimeric protein.

Gockel C, Russell M Immunology. 2005; 116(4):477-86.

PMID: 16313361 PMC: 1802434. DOI: 10.1111/j.1365-2567.2005.02246.x.

Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: a potential new strategy to target recombinant vaccine antigens to mucosal immune systems.

Harakuni T, Sugawa H, Komesu A, Tadano M, Arakawa T Infect Immun. 2005; 73(9):5654-65.

PMID: 16113283 PMC: 1231140. DOI: 10.1128/IAI.73.9.5654-5665.2005.

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