Requirement for Xist in X Chromosome Inactivation

Overview

Journal Nature

Specialty Science

Date 1996 Jan 11

PMID 8538762

Citations 562

Authors

G D Penny

G F Kay

S A Sheardown

S Rastan

N Brockdorff

Affiliations

Soon will be listed here.

Abstract

The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

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