Cell Adhesion in the Life Cycle of Dictyostelium

Overview

Journal Experientia

Specialty Science

Date 1995 Dec 18

PMID 8536805

Citations 10

Authors

S Bozzaro

E Ponte

Affiliations

Soon will be listed here.

Abstract

Three forms of cell adhesion determine the life cycle of Dictyostelium: i) adhesion of bacteria to the surface of the growing amoebae, as the prerequisite for phagocytosis; ii) cell-substrate adhesion, necessary for both locomotion of the amoebae and migration of the slug; iii) cell-cell adhesion, essential for transition from the unicellular to the multicellular stage. Intercellular adhesion has received the most attention, and fruitful approaches have been developed over the past 25 years to identify, purify and characterize cell adhesion molecules. The csA glycoprotein, in particular, which mediates adhesion during the aggregation stage, is one of the best defined cell adhesion molecules. The molecular components involved in phagocytosis and cell-substratum adhesion are less well understood, but the basis has been laid for a systematic investigation of both topics in the near future.

Citing Articles

The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.

Muller R, Herr C, Sukumaran S, Omosigho N, Plomann M, Riyahi T Cell Commun Signal. 2013; 11:54.

PMID: 23915312 PMC: 3737031. DOI: 10.1186/1478-811X-11-54.

A cytohesin homolog in Dictyostelium amoebae.

Shina M, Muller R, Blau-Wasser R, Glockner G, Schleicher M, Eichinger L PLoS One. 2010; 5(2):e9378.

PMID: 20186335 PMC: 2826412. DOI: 10.1371/journal.pone.0009378.

Involvement of Sib proteins in the regulation of cellular adhesion in Dictyostelium discoideum.

Cornillon S, Froquet R, Cosson P Eukaryot Cell. 2008; 7(9):1600-5.

PMID: 18676957 PMC: 2547077. DOI: 10.1128/EC.00155-08.

A novel Dictyostelium RasGEF required for chemotaxis and development.

Arigoni M, Bracco E, Lusche D, Kae H, Weeks G, Bozzaro S BMC Cell Biol. 2005; 6:43.

PMID: 16336640 PMC: 1325028. DOI: 10.1186/1471-2121-6-43.

Shear flow-induced detachment kinetics of Dictyostelium discoideum cells from solid substrate.

Decave E, Garrivier D, Brechet Y, Fourcade B, Bruckert F Biophys J. 2002; 82(5):2383-95.

PMID: 11964228 PMC: 1302030. DOI: 10.1016/S0006-3495(02)75583-5.

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