Are Environmental Sentinels Signaling?

Overview

Journal Environ Health Perspect

Date 1995 Oct 1

PMID 8529577

Citations 6

Authors

G A Leblanc

Affiliations

Soon will be listed here.

Abstract

There is an increasing perception that environmental contamination by chemicals no longer poses a significant health threat and that relaxation of environmental regulations is warranted. However, many wildlife populations are showing signs of developmental, behavioral, and reproductive dysfunction due to environmental contamination by endocrine-disrupting chemicals. Scientists, regulators, and legislators must mobilize to identify current health threats posed by environmental pollutants, develop testing protocols that will detect such properties of new chemicals, and strengthen legislation designed to protect environmental health.

Citing Articles

Influence of chlorine substituents on rates of oxidation of chlorinated biphenyls by the biphenyl dioxygenase of Burkholderia sp. strain LB400.

ARNETT C, Parales J, Haddock J Appl Environ Microbiol. 2000; 66(7):2928-33.

PMID: 10877788 PMC: 92093. DOI: 10.1128/AEM.66.7.2928-2933.2000.

Invertebrates in testing of environmental chemicals: are they alternatives?.

Lagadic L, Caquet T Environ Health Perspect. 1998; 106 Suppl 2:593-611.

PMID: 9599707 PMC: 1533415. DOI: 10.1289/ehp.98106593.

Environmental endocrine disruption: an effects assessment and analysis.

Crisp T, Clegg E, Cooper R, Wood W, Anderson D, Baetcke K Environ Health Perspect. 1998; 106 Suppl 1:11-56.

PMID: 9539004 PMC: 1533291. DOI: 10.1289/ehp.98106s111.

Predicting health effects of exposures to compounds with estrogenic activity: methodological issues.

Rudel R Environ Health Perspect. 1997; 105 Suppl 3:655-63.

PMID: 9168010 PMC: 1469898. DOI: 10.1289/ehp.97105s3655.

Chronic toxicity of environmental contaminants: sentinels and biomarkers.

Leblanc G, Bain L Environ Health Perspect. 1997; 105 Suppl 1:65-80.

PMID: 9114278 PMC: 1470223. DOI: 10.1289/ehp.97105s165.

References

Cassidy R, Vorhees C, Minnema D, Hastings L . The effects of chlordane exposure during pre- and postnatal periods at environmentally relevant levels on sex steroid-mediated behaviors and functions in the rat. Toxicol Appl Pharmacol. 1994; 126(2):326-37. DOI: 10.1006/taap.1994.1123. View

Hunsinger R, Howell W . Treatment of fish with hormones: solubilization and direct administration of steroids into aquaria water using acetone as a carrier solvent. Bull Environ Contam Toxicol. 1991; 47(2):272-7. DOI: 10.1007/BF01688651. View

Gray Jr L . Neonatal chlordecone exposure alters behavioral sex differentiation in female hamsters. Neurotoxicology. 1982; 3(2):67-79. View

Black H . The price of progress: environmental health in Latin America. Environ Health Perspect. 1994; 102(12):1024-8. PMC: 1567472. DOI: 10.1289/ehp.102-1567472. View

Ronis M, Ingelman-Sundberg M, Badger T . Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by ergosterol biosynthesis inhibiting fungicides (EBIFs). Biochem Pharmacol. 1994; 48(10):1953-65. DOI: 10.1016/0006-2952(94)90594-0. View

Pont A, Williams P, Azhar S, Reitz R, Bochra C, Smith E . Ketoconazole blocks testosterone synthesis. Arch Intern Med. 1982; 142(12):2137-40. View

Vom Saal F . Sexual differentiation in litter-bearing mammals: influence of sex of adjacent fetuses in utero. J Anim Sci. 1989; 67(7):1824-40. DOI: 10.2527/jas1989.6771824x. View

Fry D, Toone C . DDT-induced feminization of gull embryos. Science. 1981; 213(4510):922-4. DOI: 10.1126/science.7256288. View

Gellert R . Kepone, mirex, dieldrin, and aldrin: estrogenic activity and the induction of persistent vaginal estrus and anovulation in rats following neonatal treatment. Environ Res. 1978; 16(1-3):131-8. DOI: 10.1016/0013-9351(78)90150-0. View

10.

Ringel M, Bryan R, Vannucci R . Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers. Brain Res Dev Brain Res. 1991; 59(2):231-5. DOI: 10.1016/0165-3806(91)90103-p. View

11.

Cooper J, Vodicnik M, Gordon J . Effects of perinatal Kepone exposure on sexual differentiation of the rat brain. Neurotoxicology. 1985; 6(1):183-90. View

12.

McLachlan J . Functional toxicology: a new approach to detect biologically active xenobiotics. Environ Health Perspect. 1993; 101(5):386-7. PMC: 1519847. DOI: 10.1289/ehp.93101386. View

13.

CLAY R . A continent in chaos: Africa's environmental issues. Environ Health Perspect. 1994; 102(12):1018-23. PMC: 1567473. DOI: 10.1289/ehp.941021018. View

14.

Heckman W, Kane B, Pakyz R, Cosentino M . The effect of ketoconazole on endocrine and reproductive parameters in male mice and rats. J Androl. 1992; 13(3):191-8. View

15.

TENG C, Liu Y, Yang N, Walmer D, Panella T . Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. Mol Endocrinol. 1992; 6(11):1969-81. DOI: 10.1210/mend.6.11.1480183. View

16.

Pelissero C, Flouriot G, Foucher J, Bennetau B, Dunogues J, Le Gac F . Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals. J Steroid Biochem Mol Biol. 1993; 44(3):263-72. DOI: 10.1016/0960-0760(93)90086-c. View

17.

Sierra V, Uphouse L . Long-term consequences of neonatal exposure to chlordecone. Neurotoxicology. 1986; 7(2):609-21. View

18.

Hricko A . Environmental problems behind the Great Wall. Environ Health Perspect. 1994; 102(2):154-9. PMC: 1567195. DOI: 10.1289/ehp.94102154. View

19.

Vom Saal F, Bronson F . In utero proximity of female mouse fetuses to males: effect on reproductive performance during later life. Biol Reprod. 1978; 19(4):842-53. DOI: 10.1095/biolreprod19.4.842. View

20.

Kniewald J, Peruzovic M, Gojmerac T, MILKOVIC K, Kniewald Z . Indirect influence of s-triazines on rat gonadotropic mechanism at early postnatal period. J Steroid Biochem. 1987; 27(4-6):1095-100. DOI: 10.1016/0022-4731(87)90195-6. View