Comparative Effects of Antifungal Agents on Zidovudine Glucuronidation by Human Liver Microsomes

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1995 Jul 1

PMID 8527274

Citations 5

Authors

E Sampol

B Lacarelle

J F Rajaonarison

J Catalin

A Durand

Affiliations

Soon will be listed here.

Abstract

Zidovudine (ZDV) is extensively metabolised by the liver to an inactive glucuronide (GZDV). Since ZDV is often administered with antimycotic drugs, we studied the effect of six systemic antifungal agents on the in vitro glucuronidation of ZDV by human liver microsomes. 5-fluorocytosine and itraconazole had no inhibitory effect whereas amphotericine B, ketoconazole, miconazole and fluconazole inhibited in vitro GZDV formation (Ki values were 0.13, 0.08, 0.18 and 1.4 mM respectively).

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