Equine Infectious Anemia Virus Replication is Upregulated During Differentiation of Blood Monocytes from Acutely Infected Horses

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1996 Jan 1

PMID 8523576

Citations 7

Authors

D C Sellon

K M Walker

K E Russell

S T Perry

P Covington

F J Fuller

Affiliations

Soon will be listed here.

Abstract

Equine infectious anemia virus is a lentivirus that replicates in mature tissue macrophages of horses. Ponies were infected with equine infectious anemia virus. During febrile episodes, proviral DNA was detectable, but viral mRNA was not detectable. As cultured blood monocytes from these ponies differentiated into macrophages, viral expression was upregulated. In situ hybridization confirmed that viral transcription occurred in mature macrophages.

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References

Kono Y . Viremia and immunological responses in horses infected with equine infectious anemia virus. Natl Inst Anim Health Q (Tokyo). 1969; 9(1):1-9. View

Maury W . Monocyte maturation controls expression of equine infectious anemia virus. J Virol. 1994; 68(10):6270-9. PMC: 237047. DOI: 10.1128/JVI.68.10.6270-6279.1994. View

Kono Y, Hirasawa K, Fukunaga Y, Taniguchi T . Recrudescence of equine infectious anemia by treatment with immunosuppressive drugs. Natl Inst Anim Health Q (Tokyo). 1976; 16(1):8-15. View

Narayan O, Kennedy-Stoskopf S, Sheffer D, Griffin D, Clements J . Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. Infect Immun. 1983; 41(1):67-73. PMC: 264744. DOI: 10.1128/iai.41.1.67-73.1983. View

Montelaro R, Parekh B, Orrego A, Issel C . Antigenic variation during persistent infection by equine infectious anemia virus, a retrovirus. J Biol Chem. 1984; 259(16):10539-44. View

Salinovich O, Payne S, Montelaro R, Hussain K, Issel C, Schnorr K . Rapid emergence of novel antigenic and genetic variants of equine infectious anemia virus during persistent infection. J Virol. 1986; 57(1):71-80. PMC: 252700. DOI: 10.1128/JVI.57.1.71-80.1986. View

Stephens R, Casey J, Rice N . Equine infectious anemia virus gag and pol genes: relatedness to visna and AIDS virus. Science. 1986; 231(4738):589-94. DOI: 10.1126/science.3003905. View

Gendelman H, Narayan O, Kennedy-Stoskopf S, Kennedy P, Ghotbi Z, Clements J . Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. J Virol. 1986; 58(1):67-74. PMC: 252877. DOI: 10.1128/JVI.58.1.67-74.1986. View

Perryman L, ORourke K, McGuire T . Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection. J Virol. 1988; 62(8):3073-6. PMC: 253753. DOI: 10.1128/JVI.62.8.3073-3076.1988. View

10.

Pauza C, Galindo J, Richman D . Human immunodeficiency virus infection of monoblastoid cells: cellular differentiation determines the pattern of virus replication. J Virol. 1988; 62(10):3558-64. PMC: 253494. DOI: 10.1128/JVI.62.10.3558-3564.1988. View

11.

Rice N, Lequarre A, Casey J, Lahn S, Stephens R, Edwards J . Viral DNA in horses infected with equine infectious anemia virus. J Virol. 1989; 63(12):5194-200. PMC: 251183. DOI: 10.1128/JVI.63.12.5194-5200.1989. View

12.

Rwambo P, Issel C, Adams Jr W, Hussain K, Miller M, Montelaro R . Equine infectious anemia virus (EIAV) humoral responses of recipient ponies and antigenic variation during persistent infection. Arch Virol. 1990; 111(3-4):199-212. DOI: 10.1007/BF01311054. View

13.

Whetter L, Archambault D, Perry S, Gazit A, COGGINS L, Yaniv A . Equine infectious anemia virus derived from a molecular clone persistently infects horses. J Virol. 1990; 64(12):5750-6. PMC: 248720. DOI: 10.1128/JVI.64.12.5750-5756.1990. View

14.

ORourke K, Besola M, McGuire T . Proviral sequences detected by polymerase chain reaction in peripheral blood cells of horses with equine infectious anemia lentivirus. Arch Virol. 1991; 117(1-2):109-19. DOI: 10.1007/BF01310496. View

15.

Valentin A, von Gegerfelt A, Matsuda S, Nilsson K, Asjo B . In vitro maturation of mononuclear phagocytes and susceptibility to HIV-1 infection. J Acquir Immune Defic Syndr (1988). 1991; 4(8):751-9. View

16.

Clabough D, Gebhard D, Flaherty M, Whetter L, Perry S, COGGINS L . Immune-mediated thrombocytopenia in horses infected with equine infectious anemia virus. J Virol. 1991; 65(11):6242-51. PMC: 250322. DOI: 10.1128/JVI.65.11.6242-6251.1991. View

17.

Perry S, Flaherty M, Kelley M, Clabough D, Tronick S, COGGINS L . The surface envelope protein gene region of equine infectious anemia virus is not an important determinant of tropism in vitro. J Virol. 1992; 66(7):4085-97. PMC: 241211. DOI: 10.1128/JVI.66.7.4085-4097.1992. View

18.

Sellon D, Perry S, COGGINS L, Fuller F . Wild-type equine infectious anemia virus replicates in vivo predominantly in tissue macrophages, not in peripheral blood monocytes. J Virol. 1992; 66(10):5906-13. PMC: 241467. DOI: 10.1128/JVI.66.10.5906-5913.1992. View

19.

Levy J . Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 1993; 57(1):183-289. PMC: 372905. DOI: 10.1128/mr.57.1.183-289.1993. View

20.

Shattock R, Friedland J, Griffin G . Release of human immunodeficiency virus by THP-1 cells and human macrophages is regulated by cellular adherence and activation. J Virol. 1993; 67(6):3569-75. PMC: 237704. DOI: 10.1128/JVI.67.6.3569-3575.1993. View