Tissue Penetration of Clindamycin in Diabetic Foot Infections

Overview

Journal J Antimicrob Chemother

Publisher Oxford University Press

Specialty Infectious Diseases

Date 1993 Apr 1

PMID 8514652

Citations 11

Authors

C Duckworth

J F Fisher

S A Carter

C L Newman

C Cogburn

R R NESBIT

C H WRAY

Affiliations

Soon will be listed here.

Abstract

Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving clindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0.04-2.8 mg/kg in tissues and 1.1-11.1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0.13.

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