Ketorolac and Diclofenac for Postoperative Pain Relief Following Oral Surgery

Overview

Journal Br J Oral Maxillofac Surg

Specialties Dentistry
General Surgery

Date 1993 Jun 1

PMID 8512909

Citations 15

Authors

G M Walton

J P Rood

A T Snowdon

D Rickwood

Affiliations

Soon will be listed here.

Abstract

A double-blind clinical study was designed to compare the efficacy and safety of intramuscular and oral ketorolac, a new non-steroidal anti-inflammatory analgesic with that of diclofenac and placebo for patients undergoing removal of impacted mandibular third molar teeth. Results showed that both analgesic preparations were more effective than placebo (p = 0.0029) and that ketorolac provided a similar degree of pain relief to that of diclofenac. It is concluded that ketorolac is important new addition to the available intra-muscular NSAID preparations.

Citing Articles

Evidence-based safety profile of oral ketorolac in adults: Systematic review and meta-analysis.

Esparza-Villalpando V, Ortiz-Barroso G, Masuoka-Ito D Pharmacol Res Perspect. 2024; 12(6):e70033.

PMID: 39579063 PMC: 11584978. DOI: 10.1002/prp2.70033.

Pre-emptive analgesic efficacy of injected ketorolac in comparison to other agents for third molar surgical removal: a systematic review.

Tirupathi S, Rajasekhar S, Maloth S, Arya A, Tummalakomma P, Lanke R J Dent Anesth Pain Med. 2021; 21(1):1-14.

PMID: 33585680 PMC: 7871182. DOI: 10.17245/jdapm.2021.21.1.1.

Postoperative opioid sparing with injectable hydroxypropyl-β-cyclodextrin-diclofenac: pooled analysis of data from two Phase III clinical trials.

Gan T, Singla N, Daniels S, Hamilton D, Lacouture P, Reyes C J Pain Res. 2017; 10:15-29.

PMID: 28053554 PMC: 5191619. DOI: 10.2147/JPR.S106578.

Comparative Evaluation of Preemptive Analgesic Effect of Injected Intramuscular Diclofenac and Ketorolac after Third Molar Surgery- A Randomized Controlled Trial.

Mony D, Kulkarni D, Shetty L J Clin Diagn Res. 2016; 10(6):ZC102-6.

PMID: 27504398 PMC: 4963758. DOI: 10.7860/JCDR/2016/17696.8045.

A comparative evaluation of the effect of diclofenac sodium with and without per-orally administered methylprednisolone on the sequelae of impacted mandibular third molar removal: A cohort randomized double-blind clinical trial.

Prashar D, Pahwa D, Kalia V, Jindal G, Kaur R Indian J Dent. 2016; 7(1):11-6.

PMID: 27134449 PMC: 4836092. DOI: 10.4103/0975-962X.158187.