Pharmacologic Induction of Posterior Vitreous Detachment in the Rabbit

Overview

Journal Arch Ophthalmol

Publisher American Medical Association

Specialty Ophthalmology

Date 1993 Jun 1

PMID 8512489

Citations 24

Authors

T C Verstraeten

C Chapman

M Hartzer

B S WINKLER

M T Trese

G A Williams

Affiliations

Soon will be listed here.

Abstract

Objective: To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment.

Methods: We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed.

Results: In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy.

Conclusion: Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.

Citing Articles

Role of Single Dose of Intravitreal Recombinant Tissue Plasminogen Activator in Vitreomacular Traction and Associated Macular Edema: a Retrospective Study.

Sadhukhan K, Naskar S Maedica (Bucur). 2023; 17(4):856-861.

PMID: 36818257 PMC: 9923082. DOI: 10.26574/maedica.2022.17.4.856.

Ocriplasmin: who is the best candidate?.

Prospero Ponce C, Stevenson W, Gelman R, Agarwal D, Christoforidis J Clin Ophthalmol. 2016; 10:485-95.

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High osmolarity effect of intravitreal plasmin enzyme on rabbit retina.

Asami T, Kachi S, Mohamed U, Ito Y, Terasaki H Nagoya J Med Sci. 2015; 77(1-2):245-52.

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Lens subluxation after plasmin and SF6 injections in rabbit eyes.

Wu W, Liu C, Wang N, Chen K, Chen T, Hwang Y PLoS One. 2014; 9(11):e112957.

PMID: 25397749 PMC: 4232556. DOI: 10.1371/journal.pone.0112957.

Ocriplasmin for treatment of stage 2 macular holes: early clinical results.

Miller J, Kim L, Wu D, Vavvas D, Eliott D, Husain D Ophthalmic Surg Lasers Imaging Retina. 2014; 45(4):293-7.

PMID: 25037011 PMC: 4342757. DOI: 10.3928/23258160-20140709-05.