Crystal Structure of Cyclin-dependent Kinase 2

Overview

Journal Nature

Specialty Science

Date 1993 Jun 17

PMID 8510751

Citations 228

Authors

H L De Bondt

J Rosenblatt

J Jancarik

H D Jones

D O MORGAN

S H Kim

Affiliations

Soon will be listed here.

Abstract

Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.

Citing Articles

Copper is essential for cyclin B1-mediated CDK1 activation.

Wang J, Yang D, Yu H, Jin J, Nie Y, Zhang S Nat Commun. 2025; 16(1):2288.

PMID: 40055333 PMC: 11889272. DOI: 10.1038/s41467-025-57538-7.

Targeting cyclin-dependent kinase 2 (CDK2) interactions with cyclins and Speedy 1 (Spy1) for cancer and male contraception.

Giarolla J, Holdaway K, Nazari M, Aiad L, Sarkar B, Georg G Future Med Chem. 2025; 17(5):607-627.

PMID: 40034037 PMC: 11901406. DOI: 10.1080/17568919.2025.2463868.

Physiological and pathological roles of the transcriptional kinases CDK12 and CDK13 in the central nervous system.

Pitolli C, Marini A, Sette C, Pagliarini V Cell Death Differ. 2024; 32(3):371-381.

PMID: 39533070 PMC: 11893892. DOI: 10.1038/s41418-024-01413-3.

Discovery of pyrazole-based analogs as CDK2 inhibitors with apoptotic-inducing activity: design, synthesis and molecular dynamics study.

Ali G, Ewida M, Elmetwali A, Ewida H, George R, Mahmoud W RSC Adv. 2024; 14(47):34537-34555.

PMID: 39479486 PMC: 11520566. DOI: 10.1039/d4ra06500j.

Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs.

Karimbayli J, Pellarin I, Belletti B, Baldassarre G Mol Cancer. 2024; 23(1):135.

PMID: 38951876 PMC: 11218289. DOI: 10.1186/s12943-024-02043-6.