The Effects of Inhibition of Gluconeogenesis in Suckling Newborn Rats

Overview

Journal Biochem J

Specialty Biochemistry

Date 1977 Jan 15

PMID 849278

Citations 9

Authors

P Ferre

J P Pegorier

J Girard

Affiliations

Soon will be listed here.

Abstract

Inhibition of gluconeogenesis with 3-mercaptopicolinate in suckling newborn rats caused a fall in blood [glucose], but no change in their high plasma [free fatty acid] and blood [ketone bodies]. Active gluconeogenesis seems to be more important than sparing of glucose by high concentrations of fat-derived substrates for the maintenance of normal blood [glucose] in suckling newborn rats.

Citing Articles

Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo.

Ramnanan C, Edgerton D, Rivera N, Irimia-Dominguez J, Farmer B, Neal D Diabetes. 2010; 59(6):1302-11.

PMID: 20185816 PMC: 2874690. DOI: 10.2337/db09-1625.

Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

Edgerton D, Ramnanan C, Grueter C, Johnson K, Lautz M, Neal D Diabetes. 2009; 58(12):2766-75.

PMID: 19755527 PMC: 2780867. DOI: 10.2337/db09-0328.

Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats.

Ferre P, Satabin P, El Manoubi L, Callikan S, Girard J Biochem J. 1981; 200(2):429-33.

PMID: 7340842 PMC: 1163553. DOI: 10.1042/bj2000429.

Lactate as an oxidizable substrate for rat brain in vitro during the perinatal period.

Arizmendi C, Medina J Biochem J. 1983; 214(2):633-5.

PMID: 6615484 PMC: 1152290. DOI: 10.1042/bj2140633.

The metabolic effects of sodium dichloroacetate in the suckling newborn rat.

Pegorier J, Ferre P, Leturque A, Girard J Diabetologia. 1978; 15(6):459-63.

PMID: 728249 DOI: 10.1007/BF02342870.

References

LUCKEY T, MENDE T, PLEASANTS J . The physical and chemical characterization of rat's milk. J Nutr. 1954; 54(3):345-59. DOI: 10.1093/jn/54.3.345. View

Girard J, Guillet I, Marty J, Assan R, Marliss E . Effects of exogenous hormones and glucose on plasma levels and hepatic metabolism of amino acids in the fetus and in the newborn rat. Diabetologia. 1976; 12(4):327-37. DOI: 10.1007/BF00420976. View

Page M, KREBS H, Williamson D . Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats. Biochem J. 1971; 121(1):49-53. PMC: 1176485. DOI: 10.1042/bj1210049. View

Ditullio N, Berkoff C, Blank B, Kostos V, Stack E, Saunders H . 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem J. 1974; 138(3):387-94. PMC: 1166224. DOI: 10.1042/bj1380387. View

Snell K, Walker D . Gluconeogenesis in the newborn rat: the substrates and their quantitative significance. Enzyme. 1973; 15(1):40-81. View

KREISBERG R, Siegal A, Owen W . Alanine and gluconeogenesis in man: effect of ethanol. J Clin Endocrinol Metab. 1972; 34(5):876-83. DOI: 10.1210/jcem-34-5-876. View

Vernon R, Walker D . Glycerol metabolism in the neonatal rat. Biochem J. 1970; 118(3):531-6. PMC: 1179222. DOI: 10.1042/bj1180531. View

Girard J, Cuendet G, Marliss E, Kervran A, Rieutort M, Assan R . Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat. J Clin Invest. 1973; 52(12):3190-200. PMC: 302595. DOI: 10.1172/JCI107519. View

Spydervold O, McLean P, Greenbaum A . The effect of quinolinic acid on the content and distribution of hepatic metabolites. Arch Biochem Biophys. 1974; 164(2):590-601. DOI: 10.1016/0003-9861(74)90071-x. View

10.

Vernon R, Walker D . Changes in activity of some enzymes involved in glucose utilization and formation in developing rat liver. Biochem J. 1968; 106(2):321-9. PMC: 1198506. DOI: 10.1042/bj1060321. View

11.

Williamson D, Lund P, KREBS H . The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J. 1967; 103(2):514-27. PMC: 1270436. DOI: 10.1042/bj1030514. View

12.

Schramm V, Hanson R . Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP). J Biol Chem. 1976; 251(1):37-44. View

13.

Girard J, Guillet I, Marty J, Marliss E . Plasma amino acid levels and development of hepatic gluconeogenesis in the newborn rat. Am J Physiol. 1975; 229(2):466-73. DOI: 10.1152/ajplegacy.1975.229.2.466. View

14.

Blackshear P, Holloway P, Aberti K . The effects of inhibition of gluconeogenesis on ketogenesis in starved and diabetic rats. Biochem J. 1975; 148(3):353-62. PMC: 1165552. DOI: 10.1042/bj1480353b. View

15.

Girard J, Kervran A, Soufflet E, Assan R . Factors affecting the secretion of insulin and glucagon by the rat fetus. Diabetes. 1974; 23(4):310-7. DOI: 10.2337/diab.23.4.310. View

16.

Snell K, Walker D . Glucose metabolism in the newborn rat. Temporal studies in vivo. Biochem J. 1973; 132(4):739-52. PMC: 1177649. DOI: 10.1042/bj1320739. View

17.

Vernon R, Walker D . Glucose metabolism in the developing rat. Studies in vivo. Biochem J. 1972; 127(3):521-9. PMC: 1178693. DOI: 10.1042/bj1270521. View

18.

Ho R . Radiochemical assay of long-chain fatty acids using 63Ni as tracer. Anal Biochem. 1970; 36(1):105-13. DOI: 10.1016/0003-2697(70)90337-4. View

19.

Ballard F, Hanson R . Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Biochem J. 1967; 104(3):866-71. PMC: 1271226. DOI: 10.1042/bj1040866. View