A Gene Apparently Determining the Extent of Sialylation of Lysosomal Alpha-mannosidase in Mouse Liver

Overview

Journal Biochem Genet

Specialty Molecular Biology

Date 1977 Feb 1

PMID 849251

Citations 21

Authors

M Dizik

R W Elliott

Affiliations

Soon will be listed here.

Abstract

Organ-specific electrophoretic heterogeneity of lysosomal alpha-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal alpha-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.

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