Effect of Fluvastatin Sodium (XU62-320), a New Inhibitor of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase, on the Induction of Low-density Lipoprotein Receptor in HepG2 Cells

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1993 Apr 7

PMID 8466953

Citations 6

Authors

K Hayashi

J Kurokawa

S Nomura

Y Kuga

Y Ohkura

G Kajiyama

Affiliations

Soon will be listed here.

Abstract

The effect of fluvastatin sodium (XU62-320), a new type of inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A, on the induction of LDL receptor in the human liver-derived cell line HepG2 was investigated. Fluvastatin sodium produced marked inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and induction of LDL receptor on HepG2 cells at a concentration of 0.1-1.0 microM. These results suggest that fluvastatin sodium has potential for use as a strong plasma cholesterol-lowering drug.

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