Characterization of Enterotoxigenic Escherichia Coli Isolated from U.S. Troops Deployed to the Middle East

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1993 Apr 1

PMID 8463396

Citations 28

Authors

M K Wolf

D N Taylor

E C Boedeker

K C Hyams

D R Maneval

M M Levine

K Tamura

R A Wilson

P Echeverria

Affiliations

Soon will be listed here.

Abstract

Enterotoxigenic Escherichia coli (ETEC) was a common cause of traveler's diarrhea in U.S. soldiers in the Middle East in 1989 and 1990. To determine which bacterial components would be useful in a vaccine, potential protective antigens (toxin, colonization factor antigen [CFA], and serotype) from 189 ETEC isolates were examined. Nearly half of the isolates expressed both ETEC toxins, 39% had only heat-stable enterotoxin (ST), and 17% had heat-labile enterotoxin (LT). CFA/I was the least common colonization factor antigen (11%), CFA/II was common (34%), as was CFA/IV (31%), and 24% expressed none of these CFAs. Fifty-seven O:H serotypes were found. Serotype O6:H16 was the most common, occurring in 29% of the ETEC isolates, usually with LT-ST and CFA/II. Generally, CFA/II was associated with expression of both toxins, CFA/IV was associated with expression of ST, and none of the CFAs was routinely found with LT. We conclude that ETEC from soldiers in the Middle East expressed a variety of antigens and that an effective vaccine will require multiple protective antigens.

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