Insulin Resistance and Mechanical Dysfunction in Hearts of Wistar Rats with Streptozotocin-induced Non-insulin-dependent Diabetes Mellitus

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1993 Mar 1

PMID 8462767

Citations 4

Authors

S W Schaffer

G L Wilson

Affiliations

Soon will be listed here.

Abstract

The present study correlates the insulin resistance seen in the myocardium of rats with streptozotocin-induced non-insulin-dependent diabetes mellitus with insulin secretory defects, hyperglycaemia and disease duration. Two-day-old male Wistar rats were given a bolus injection of streptozotocin (0.09 mg/g body weight) which caused glucose intolerance when these animals reached adulthood. Although these rats developed a progressive resistance to the actions of insulin in the heart this did not correlate with the development of glucose intolerance. However, a correlation was seen with a shift in insulin secretory response from hyper- to hypo-secretion which developed between 6 and 14 months of age. Moreover, this shift in secretory pattern can be associated with the onset of a cardiac mechanical malfunction.

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Insulin resistance and mechanical dysfunction in hearts of Wistar rats with streptozotocin-induced non-insulin-dependent diabetes mellitus.

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