Influence of a Stationary Magnetic Field on Acetylcholinesterase in Murine Bone Marrow Cells

Overview

Journal Radiat Environ Biophys

Specialties Biophysics
Environmental Health
Oncology
Radiology

Date 1993 Jan 1

PMID 8460216

Citations 2

Authors

S Stegemann

K I ALTMAN

H Muhlensiepen

L E Feinendegen

Affiliations

Soon will be listed here.

Abstract

A thirty-minute exposure of mice to a homogeneous stationary magnetic field (SMF) of 1.4 Tesla at either 27 degrees C or 37 degrees C body temperature causes an inhibition of about 20 per cent of acetylcholinesterase (AChE, E.C. 3.11.7) in murine bone marrow cells (BMC) after 3.5 and 2 h, respectively, at the two aforementioned body temperatures. The extent of enzyme inhibition is independent of ambient temperature, but dependent on the time after exposure. This initial inhibition of AChE activity is followed by a limited recovery which is dependent upon the temperature during exposure to the SMF and remains incomplete even 15 h afterwards. We describe here certain enzymologic properties of AChE in BMC as well as inhibition studies with diisopropylfluorophosphate (DFP) to differentiate between AChE and nonspecific cholinesterases.

Citing Articles

A Further Investigation of the Effects of Extremely Low Frequency Magnetic Fields on Alkaline Phosphatase and Acetylcholinesterase.

Silkstone G, Wilson M PLoS One. 2016; 11(3):e0148369.

PMID: 26963611 PMC: 4786325. DOI: 10.1371/journal.pone.0148369.

Safety concerns related to magnetic field exposure.

Silva A, Silva E, Egito E, Carrico A Radiat Environ Biophys. 2006; 45(4):245-52.

PMID: 17021785 DOI: 10.1007/s00411-006-0065-0.

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