A Model of Stereociliary Tip-link Stretches

Overview

Journal Hear Res

Specialty Otorhinolaryngology

Date 1993 Feb 1

PMID 8458761

Citations 9

Authors

C D Geisler

Affiliations

Soon will be listed here.

Abstract

A model of the tip-link stretches produced by angular deflections of the stereocilia of vertebrate acoustico-lateralis hair cells is presented. It is shown that tip-link stretch in the model is proportional to the angle of stereociliary deflection. By contrast, the stretch of a horizontal (e.g., row-to-row) link is proportional to the square of the angle of stereociliary deflection. Possible roles of these stretches in sensory transduction are discussed.

Citing Articles

LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.

Beurg M, Schwalbach E, Fettiplace R Proc Natl Acad Sci U S A. 2024; 121(3):e2318270121.

PMID: 38194445 PMC: 10801851. DOI: 10.1073/pnas.2318270121.

Dimensions of a Living Cochlear Hair Bundle.

Miller K, Atkinson P, Mendoza K, O Maoileidigh D, Grillet N Front Cell Dev Biol. 2021; 9:742529.

PMID: 34900993 PMC: 8657763. DOI: 10.3389/fcell.2021.742529.

The physiology of mechanoelectrical transduction channels in hearing.

Fettiplace R, Kim K Physiol Rev. 2014; 94(3):951-86.

PMID: 24987009 PMC: 4101631. DOI: 10.1152/physrev.00038.2013.

Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.

Indzhykulian A, Stepanyan R, Nelina A, Spinelli K, Ahmed Z, Belyantseva I PLoS Biol. 2013; 11(6):e1001583.

PMID: 23776407 PMC: 3679001. DOI: 10.1371/journal.pbio.1001583.

Sliding adhesion confers coherent motion to hair cell stereocilia and parallel gating to transduction channels.

Karavitaki K, Corey D J Neurosci. 2010; 30(27):9051-63.

PMID: 20610739 PMC: 2932470. DOI: 10.1523/JNEUROSCI.4864-09.2010.