A Double Life: Cytosolic Aconitase As a Regulatory RNA Binding Protein

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 1993 Jan 1

PMID 8443405

Citations 24

Authors

R D Klausner

T A Rouault

Affiliations

Soon will be listed here.

Citing Articles

Non-Mitochondrial Aconitase-2 Mediates the Transcription of Nuclear-Encoded Electron Transport Chain Genes in Fission Yeast.

Kim H, Cho S, Jung S, Cho Y, Roe J, Kim K J Microbiol. 2024; 62(8):639-648.

PMID: 38916790 DOI: 10.1007/s12275-024-00147-8.

Heat stress alters the ovarian proteome in prepubertal gilts.

Roach C, Mayorga E, Baumgard L, Ross J, Keating A J Anim Sci. 2024; 102.

PMID: 38605681 PMC: 11025630. DOI: 10.1093/jas/skae053.

Norcantharidin down-regulates iron contents in the liver and spleen of lipopolysaccharide-treated mice.

Zheng J, Wang J, Ma H, Shen M, Qian Z, Bao Y Redox Rep. 2022; 27(1):119-127.

PMID: 35735222 PMC: 9246006. DOI: 10.1080/13510002.2022.2088011.

Proteome plasticity in response to persistent environmental change.

Domnauer M, Zheng F, Li L, Zhang Y, Chang C, Unruh J Mol Cell. 2021; 81(16):3294-3309.e12.

PMID: 34293321 PMC: 8475771. DOI: 10.1016/j.molcel.2021.06.028.

Mitochondrial HMG-Box Containing Proteins: From Biochemical Properties to the Roles in Human Diseases.

Vozarikova V, Kunova N, Bauer J, Frankovsky J, Kotrasova V, Prochazkova K Biomolecules. 2020; 10(8).

PMID: 32824374 PMC: 7463775. DOI: 10.3390/biom10081193.

References

Shows T, Brown J . Mapping AK1, ACONs, and AK3 to chromosome 9 in man employing and X/9 translocation and somatic cell hybrids. Cytogenet Cell Genet. 1977; 19(1):26-37. DOI: 10.1159/000130791. View

Haile D, Rouault T, Tang C, Chin J, Harford J, Klausner R . Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster. Proc Natl Acad Sci U S A. 1992; 89(16):7536-40. PMC: 49745. DOI: 10.1073/pnas.89.16.7536. View

Hentze M, Rouault T, Harford J, Klausner R . Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science. 1989; 244(4902):357-9. DOI: 10.1126/science.2711187. View

Robbins A, Stout C . Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal. Proc Natl Acad Sci U S A. 1989; 86(10):3639-43. PMC: 287193. DOI: 10.1073/pnas.86.10.3639. View

Walden W, Patino M, Gaffield L . Purification of a specific repressor of ferritin mRNA translation from rabbit liver. J Biol Chem. 1989; 264(23):13765-9. View

Rouault T, Hentze M, Haile D, Harford J, Klausner R . The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein. Proc Natl Acad Sci U S A. 1989; 86(15):5768-72. PMC: 297711. DOI: 10.1073/pnas.86.15.5768. View

Robbins A, Stout C . The structure of aconitase. Proteins. 1989; 5(4):289-312. DOI: 10.1002/prot.340050406. View

Klausner R, Harford J . cis-trans models for post-transcriptional gene regulation. Science. 1989; 246(4932):870-2. DOI: 10.1126/science.2683086. View

BEINERT H, Kennedy M . 19th Sir Hans Krebs lecture. Engineering of protein bound iron-sulfur clusters. A tool for the study of protein and cluster chemistry and mechanism of iron-sulfur enzymes. Eur J Biochem. 1989; 186(1-2):5-15. DOI: 10.1111/j.1432-1033.1989.tb15170.x. View

10.

Haile D, Hentze M, Rouault T, Harford J, Klausner R . Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements. Mol Cell Biol. 1989; 9(11):5055-61. PMC: 363657. DOI: 10.1128/mcb.9.11.5055-5061.1989. View

11.

Switzer R . Non-redox roles for iron-sulfur clusters in enzymes. Biofactors. 1989; 2(2):77-86. View

12.

Neupert B, Thompson N, Meyer C, Kuhn L . A high yield affinity purification method for specific RNA-binding proteins: isolation of the iron regulatory factor from human placenta. Nucleic Acids Res. 1990; 18(1):51-5. PMC: 330202. DOI: 10.1093/nar/18.1.51. View

13.

Rothenberger S, Mullner E, Kuhn L . The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Nucleic Acids Res. 1990; 18(5):1175-9. PMC: 330432. DOI: 10.1093/nar/18.5.1175. View

14.

Barton H, Eisenstein R, Bomford A, MUNRO H . Determinants of the interaction between the iron-responsive element-binding protein and its binding site in rat L-ferritin mRNA. J Biol Chem. 1990; 265(12):7000-8. View

15.

BEINERT H . Recent developments in the field of iron-sulfur proteins. FASEB J. 1990; 4(8):2483-91. DOI: 10.1096/fasebj.4.8.2185975. View

16.

Rouault T, Tang C, Kaptain S, Burgess W, Haile D, Samaniego F . Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein. Proc Natl Acad Sci U S A. 1990; 87(20):7958-62. PMC: 54871. DOI: 10.1073/pnas.87.20.7958. View

17.

Rouault T, Stout C, Kaptain S, Harford J, Klausner R . Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implications. Cell. 1991; 64(5):881-3. DOI: 10.1016/0092-8674(91)90312-m. View

18.

Hentze M, Argos P . Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase. Nucleic Acids Res. 1991; 19(8):1739-40. PMC: 328097. DOI: 10.1093/nar/19.8.1739. View

19.

Cox T, Bawden M, Martin A, May B . Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA. EMBO J. 1991; 10(7):1891-902. PMC: 452864. DOI: 10.1002/j.1460-2075.1991.tb07715.x. View

20.

Dandekar T, Stripecke R, Gray N, Goossen B, Constable A, Johansson H . Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA. EMBO J. 1991; 10(7):1903-9. PMC: 452865. DOI: 10.1002/j.1460-2075.1991.tb07716.x. View