Convergence of Olfactory and Nasotrigeminal Inputs and Possible Trigeminal Contributions to Olfactory Responses in the Rat Thalamus

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 1993 Jan 1

PMID 8442943

Citations 8

Authors

A Inokuchi

C P Kimmelman

J B SNOW Jr

Affiliations

Soon will be listed here.

Abstract

To elucidate the role of trigeminal input on the olfactory system, field-evoked potentials were measured following electrical stimulation of the nasociliary branch of the trigeminal nerve in the olfactory-related structures in the rat brain. Significant potential changes were recorded in the mediodorsal nucleus of the thalamus and the lateral hypothalamic area. In the mediodorsal nucleus of the thalamus, the neurons responding to olfactory bulb electrical stimulation also responded to trigeminal nerve stimulation. Single neuronal responses of mediodorsal thalamic neurons following odorant stimulation were enhanced by blockade of the trigeminal nerve with procaine. These results suggest that olfactory and trigeminal pathways converge on the same neural elements within the mediodorsal nucleus of the thalamus and that the trigeminal input may modulate olfactory input in this nucleus.

Citing Articles

Hot topic: Mapping of the human intranasal mucosal thermal sensitivity: A clinical study on thermal threshold and trigeminal receptors.

Weise S, Hanslik P, Mignot C, Glushkov E, Bertsch A, Dubreuil R PLoS One. 2024; 19(8):e0304874.

PMID: 39106272 PMC: 11302907. DOI: 10.1371/journal.pone.0304874.

Olfactory-trigeminal integration in the primary olfactory cortex.

Karunanayaka P, Lu J, Elyan R, Yang Q, Sathian K Hum Brain Mapp. 2024; 45(10):e26772.

PMID: 38962966 PMC: 11222875. DOI: 10.1002/hbm.26772.

Human Primary Olfactory Amygdala Subregions Form Distinct Functional Networks, Suggesting Distinct Olfactory Functions.

Noto T, Zhou G, Yang Q, Lane G, Zelano C Front Syst Neurosci. 2021; 15:752320.

PMID: 34955769 PMC: 8695617. DOI: 10.3389/fnsys.2021.752320.

Linalool odor-induced analgesia is triggered by TRPA1-independent pathway in mice.

Kashiwadani H, Higa Y, Sugimura M, Kuwaki T Behav Brain Funct. 2021; 17(1):3.

PMID: 33902628 PMC: 8077846. DOI: 10.1186/s12993-021-00176-y.

Pleasantness and trigeminal sensations as salient dimensions in organizing the semantic and physiological spaces of odors.

Licon C, Manesse C, Dantec M, Fournel A, Bensafi M Sci Rep. 2018; 8(1):8444.

PMID: 29855500 PMC: 5981304. DOI: 10.1038/s41598-018-26510-5.

References

Imamura K, Onoda N, TAKAGI S . Odor response characteristics of thalamic mediodorsal nucleus neurons in the rabbit. Jpn J Physiol. 1984; 34(1):55-73. DOI: 10.2170/jjphysiol.34.55. View

BENJAMIN R, Jackson J, Golden G . Cortical projections of the thalamic mediodorsal nucleus in the rabbit. Brain Res. 1978; 141(2):251-65. DOI: 10.1016/0006-8993(78)90196-8. View

KRETTEK J, Price J . The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat. J Comp Neurol. 1977; 171(2):157-91. DOI: 10.1002/cne.901710204. View

Jackson J, BENJAMIN R . Unit discharges in the mediodorsal nucleus of the rabbit evoked by electrical stimulation of the olfactory bulb. Brain Res. 1974; 75(2):193-201. DOI: 10.1016/0006-8993(74)90741-0. View

Allison T, Goff W . Human cerebral evoked responses to odorous stimuli. Electroencephalogr Clin Neurophysiol. 1967; 23(6):558-60. DOI: 10.1016/0013-4694(67)90022-3. View

Smith R . The ascending fiber projections from the principal sensory trigeminal nucleus in the rat. J Comp Neurol. 1973; 148(4):423-45. DOI: 10.1002/cne.901480403. View

ULRICH C, Haddock M, Alarie Y . Airborne chemical irritants. Role of the trigeminal nerve. Arch Environ Health. 1972; 24(1):37-42. DOI: 10.1080/00039896.1972.10666047. View

BENJAMIN R, Jackson J, Golden G, West C . Sources of olfactory inputs to opossum mediodorsal nucleus identified by horseradish peroxidase and autoradiographic methods. J Comp Neurol. 1982; 207(4):358-68. DOI: 10.1002/cne.902070407. View

Bojsen-Moller F . Demonstration of terminalis, olfactory, trigeminal and perivascular nerves in the rat nasal septum. J Comp Neurol. 1975; 159(2):245-56. DOI: 10.1002/cne.901590206. View

10.

Karamanlidis A, Michaloudi H, Mangana O, Saigal R . Trigeminal ascending projections in the rabbit, studied with horseradish peroxidase. Brain Res. 1978; 156(1):110-6. DOI: 10.1016/0006-8993(78)90085-9. View

11.

Inokuchi A, Kimmelman C, Wang H, SNOW Jr J . Olfactory evoked potentials in the rat. Laryngoscope. 1986; 96(10):1107-11. DOI: 10.1288/00005537-198610000-00011. View

12.

Heimer L . The olfactory connections of the diencephalon in the rat. An experimental light- and electron-microscopic study with special emphasis on the problem of terminal degeneration. Brain Behav Evol. 1972; 6(1):484-523. DOI: 10.1159/000123728. View

13.

Stone H, Rebert C . Observations on trigeminal olfactory interactions. Brain Res. 1970; 21(1):138-42. DOI: 10.1016/0006-8993(70)90030-2. View

14.

Cain W, Murphy C . Interaction between chemoreceptive modalities of odour and irritation. Nature. 1980; 284(5753):255-7. DOI: 10.1038/284255a0. View

15.

Hockfield S, Gobel S . Neurons in and near nucleus caudalis with long ascending projection axons demonstrated by retrograde labeling with horseradish peroxidase. Brain Res. 1978; 139(2):333-9. DOI: 10.1016/0006-8993(78)90933-2. View

16.

Silver W, Mason J, Marshall D, Maruniak J . Rat trigeminal, olfactory and taste responses after capsaicin desensitization. Brain Res. 1985; 333(1):45-54. DOI: 10.1016/0006-8993(85)90122-2. View

17.

KERR F . THE DIVISIONAL ORGANIZATION OF AFFERENT FIBRES OF THE TRIGEMINAL NERVE. Brain. 1963; 86:721-32. DOI: 10.1093/brain/86.4.721. View