The Immunoglobulin Heavy Chain Locus Contains Another B-cell-specific 3' Enhancer Close to the Alpha Constant Region

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1993 Mar 1

PMID 8441396

Citations 23

Authors

P Matthias

D Baltimore

Affiliations

Soon will be listed here.

Abstract

The transcription of immunoglobulin genes is controlled by variable region promoters and by enhancers, both of which are lymphoid specific. Because immunoglobulin genes are subject to an extremely complex regulation, we anticipated that there might be additional control elements for these genes. We therefore sought additional enhancers and demonstrate here that there is indeed another weak transcriptional enhancer just 3' to the mouse alpha constant region. This novel immunoglobulin enhancer is lymphoid specific and at two positions can bind members of the Oct family of transcription factors.

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