Non-immunological Risk Factors in Paediatric Renal Transplantation

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 1993 Feb 1

PMID 8439491

Citations 6

Authors

M F Gagnadoux

P Niaudet

M Broyer

Affiliations

Soon will be listed here.

Abstract

In paediatric renal transplantation, non-immunological risk factors account for about one-third of graft losses. Recurrence of original disease is observed mainly in primary hyperoxaluria and glomerulopathies such as steroid-resistant nephrotic syndrome and membranoproliferative glomerulonephritis. In both glomerulopathies, 20% of grafts are lost from recurrence. Vascular thrombosis is, in most series, the second cause of graft loss in children, particularly in young recipients or with young donors (under 5 years of age). Non-compliance with treatment is a common non-immunological factor in adolescent recipients, which may trigger a severe rejection process resulting in graft loss. The role of factors related to graft preservation and intra- and post-operative management (ischaemia time, delayed graft function) or to cytomegalovirus infection is less obvious in our series. Prevention of vascular thrombosis and of non-compliance is most important in order to improve the results of paediatric renal transplantation.

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References

De Pauw L, Watts R, Danpure C, Toussaint C . [Which transplantation strategies in primary hyperoxaluria type 1?]. Nephrologie. 1991; 12(3):147-9. View

Broyer M, Brunner F, Brynger H, Dykes S, Ehrich J, Fassbinder W . Kidney transplantation in primary oxalosis: data from the EDTA Registry. Nephrol Dial Transplant. 1990; 5(5):332-6. DOI: 10.1093/ndt/5.5.332. View

Barry J, Lieberman S, Wickre C, Lieberman C, Fischer S, Craig D . Human kidney preservation by intracellular electrolyte flush followed by cold storage for over 24 hours. Transplantation. 1981; 32(6):485-7. DOI: 10.1097/00007890-198112000-00006. View

Lui S, Moorhead J, Varghese Z, Miscony M, Sweny P, Fernando O . Successful renal transplantation with cadaveric donor kidneys of extremely prolonged cold ischaemic time. Nephrol Dial Transplant. 1987; 2(5):371-5. View

Hebert D, Kim E, Sibley R, Mauer M . Post-transplantation outcome of patients with hemolytic-uremic syndrome: update. Pediatr Nephrol. 1991; 5(1):162-7. DOI: 10.1007/BF00852876. View

Muller G, Hohn U, Greger B, Schareck W, Hopt U, Lauchart W . Effect of anastomosis time and intraoperative organ cooling on primary function in renal transplantation. Transplant Proc. 1989; 21(1 Pt 2):1239. View

Beurton D, Tremeaux J, Terdjman S, Hacker P, Charbit L, Gonties D . [Surgical complications of renal transplantation in children. Retrospective study of 372 cases]. J Urol (Paris). 1987; 93(5):245-51. View

Churchill B, Mclorie G, Williot P, Merguerian P . Influence of early function on long-term pediatric cadaveric renal allograft survival. J Urol. 1990; 143(2):326-9. DOI: 10.1016/s0022-5347(17)39949-4. View

Martin S, Morris D, Dyer P, Gokal R, Mallick N, Johnson R . The association between cytomegalovirus-specific antibodies, lymphocytotoxic antibodies, HLA-DR phenotype, and graft outcome in renal transplant recipients. Transplantation. 1991; 51(6):1303-5. View

10.

KATZ S, Kerman R, Golden D, Grevel J, Camel S, Lewis R . Preemptive transplantation--an analysis of benefits and hazards in 85 cases. Transplantation. 1991; 51(2):351-5. View

11.

Ettenger R, Rosenthal J, Marik J, Malekzadeh M, Forsythe S, Kamil E . Improved cadaveric renal transplant outcome in children. Pediatr Nephrol. 1991; 5(1):137-42. DOI: 10.1007/BF00852871. View

12.

Nevins T, DANIELSON G . Prior dialysis does not affect the outcome of pediatric renal transplantation. Pediatr Nephrol. 1991; 5(2):211-4. DOI: 10.1007/BF01095954. View

13.

Najarian J, Frey D, Matas A, Gillingham K, So S, Cook M . Renal transplantation in infants. Ann Surg. 1990; 212(3):353-65; discussion 366-7. PMC: 1358172. DOI: 10.1097/00000658-199009000-00014. View

14.

Rosenthal J, Danovitch G, Wilkinson A, Ettenger R . The high cost of delayed graft function in cadaveric renal transplantation. Transplantation. 1991; 51(5):1115-8. View

15.

Bryant J, Joseph D, Kohaut E, Diethelm A . Renal transplantation in children with posterior urethral valves. J Urol. 1991; 146(6):1585-7. DOI: 10.1016/s0022-5347(17)38173-9. View

16.

Harmon W, Stablein D, Alexander S, Tejani A . Graft thrombosis in pediatric renal transplant recipients. A report of the North American Pediatric Renal Transplant Cooperative Study. Transplantation. 1991; 51(2):406-12. DOI: 10.1097/00007890-199102000-00026. View

17.

Alexander S, Arbus G, Butt K, Conley S, Fine R, GREIFER I . The 1989 report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol. 1990; 4(5):542-53. DOI: 10.1007/BF00869842. View

18.

Broyer M, Mitsioni A, Habib R . [Early failures in kidney transplantation. A retrospective study of 53 cases]. Ann Pediatr (Paris). 1990; 37(2):87-90. View

19.

Gokal R, Ramos J, Veitch P, Proud G, Taylor R, Ward M . Renal transplantation in patients on continuous ambulatory peritoneal dialysis. Proc Eur Dial Transplant Assoc. 1981; 18:222-7. View

20.

Bassani C, Ferraris J, GIANANTONIO C, Ruiz S, Ramirez J . Renal transplantation in patients with classical haemolytic-uraemic syndrome. Pediatr Nephrol. 1991; 5(5):607-11. DOI: 10.1007/BF00856651. View