The Effect of Metal Ions on the Activity of Delta-aminolevulinic Acid Dehydratase

Overview

Journal Br J Ind Med

Specialty Occupational Medicine

Date 1977 Feb 1

PMID 843461

Citations 6

Authors

J Thompson

D D Jones

W H Beasley

Affiliations

Soon will be listed here.

Abstract

The effects of lead, iron, copper, and zinc ions on delta-aminolevulinic acid dehydratase from red blood cell haemolysates in humans, both in the absence and presence of plasma proteins, have been investigated. delta-aminolevulinic acid dehydratase (ALAD) was not found to be a specific indicator of blood lead concentrations since it was also inhibited by copper and activated by zinc. Plasma protein protected the enzyme from both inhibition and activation. ALAD activity was found to be an indicator of the total metal ion concentration in the blood and was therefore considered to be of doubtful value in screening large populations for increased lead absorption.

Citing Articles

Interaction of metals from group 10 (Ni, Pd, and Pt) and 11 (Cu, Ag, and Au) with human blood δ-ALA-D: in vitro and in silico studies.

Klimaczewski C, Nogara P, Barbosa N, da Rocha J Environ Sci Pollut Res Int. 2018; 25(30):30557-30566.

PMID: 30173384 DOI: 10.1007/s11356-018-3048-1.

From bortezomib to other inhibitors of the proteasome and beyond.

Buac D, Shen M, Schmitt S, Kona F, Deshmukh R, Zhang Z Curr Pharm Des. 2012; 19(22):4025-38.

PMID: 23181572 PMC: 3657018. DOI: 10.2174/1381612811319220012.

The in vivo effects of zinc on erythrocyte delta-aminolaevulinic acid dehydratase in man.

MEREDITH P, Moore M Int Arch Occup Environ Health. 1980; 45(2):163-8.

PMID: 7364492 DOI: 10.1007/BF01274135.

Erythrocyte factors concerned in the inhibition of ALA-D by lead.

Sakai T, Yanagihara S, Ushio K Br J Ind Med. 1981; 38(3):268-74.

PMID: 7272240 PMC: 1008885. DOI: 10.1136/oem.38.3.268.

Mechanisms of ALA-D inhibition by lead and of its restoration by zinc and dithiothreitol.

Sakai T, Yanagihara S, Kunugi Y, Ushio K Br J Ind Med. 1983; 40(1):61-6.

PMID: 6824601 PMC: 1009119. DOI: 10.1136/oem.40.1.61.

References

BONSIGNORE D . [Delta-aminolevulinate dehydratase activity of erythrocytes as a diagnostic test in occupational lead poisoning]. Med Lav. 1966; 57(11):647-54. View

. Proceedings of the Biochemical Society. Biochem J. 1954; 57(3):xvii-xxv. PMC: 1269793. View

Gibson K, Neuberger A, Scott J . The purification and properties of delta-aminolaevulic acid dehydrase. Biochem J. 1955; 61(4):618-29. PMC: 1215844. DOI: 10.1042/bj0610618. View

LICHTMAN H, Feldman F . In vitro pyrrole and porphyrin synthesis in lead poisoning and iron deficiency. J Clin Invest. 1963; 42:830-9. PMC: 289353. DOI: 10.1172/JCI104775. View

Passow H, Rothstein A, Clarkson T . The general pharmacology of the heavy metals. Pharmacol Rev. 1961; 13:185-224. View

Lauwerys R, Buchet J, Roels H . Comparative study of effect of inorganic lead and cadmium on blood delta-aminolevulinate dehydratase in man. Br J Ind Med. 1973; 30(4):359-64. PMC: 1069476. DOI: 10.1136/oem.30.4.359. View

HERNBERG S, Nikkanen J, Mellin G, Lilius H . Delta-aminolevulinic acid dehydrase as a measure of lead exposure. Arch Environ Health. 1970; 21(2):140-5. DOI: 10.1080/00039896.1970.10667211. View

Beattie A, Moore M, GOLDBERG A . Tetraethyl-lead poisoning. Lancet. 1972; 2(7766):12-5. DOI: 10.1016/s0140-6736(72)91276-7. View

HAEGER-ARONSEN B, Abdulla M, FRISTEDT B . Effect of lead on -aminolevulinic acid dehydrase activity in red blood cells. Arch Environ Health. 1971; 23(6):440-5. DOI: 10.1080/00039896.1971.10666033. View

10.

Millar J, Thompson G, GOLDBERG A, Barry P, LOWE E . -Aminolevulinic acid dehydrase activity in the blood of men working with lead alkyls. Br J Ind Med. 1972; 29(3):317-20. PMC: 1009430. DOI: 10.1136/oem.29.3.317. View

11.

Abdulla M, HAEGER-ARONSEN B . ALA-dehydratase activation by zinc. Enzyme. 1971; 12(6):708-10. DOI: 10.1159/000459608. View

12.

Weissberg J, Lipschutz F, Oski F . Delta-aminolevulinic acid dehydratase activity in circulating blood cells. A sensitive laboratory test for the detection of childhood lead poisoning. N Engl J Med. 1971; 284(11):565-9. DOI: 10.1056/NEJM197103182841101. View

13.

Delves H . A micro-sampling method for the rapid determination of lead in blood by atomic-absorption spectrophotometry. Analyst. 1970; 95(130):431-8. DOI: 10.1039/an9709500431. View

14.

Nakao K, Wada O, Yano Y . Delta-aminolevulinic acid dehydratase activity in erythrocytes for the evaluation of lead poisoning. Clin Chim Acta. 1968; 19(2):319-25. DOI: 10.1016/0009-8981(68)90341-0. View