Map of Seven Polymorphic Markers on Rat Chromosome 14: Linkage Conservation with Human Chromosome 4

Overview

Journal Mamm Genome

Specialty Genetics

Date 1993 Jan 1

PMID 8431642

Citations 3

Authors

E F Remmers

E A Goldmuntz

J M Cash

H Zha

L J Crofford

P Mathern

R L Wilder

Affiliations

Soon will be listed here.

Abstract

Seven polymorphic markers identified by polymerase chain reaction (PCR) amplification, including markers for six genes--DRD1L (dopamine receptor, D1-like-2), GLUKA (glucokinase), PF4 (platelet factor 4), ALB (albumin), AFP (alpha-fetoprotein), and BSP (bone sialoprotein)--and one anonymous locus (D14N52), were mapped to a single 67-cM linkage group with F2 intercross progeny of F344/N and LEW/N inbred rat strains. Two of these markers, ALB and AFP, have previously been assigned to rat Chromosome (Chr) 14, allowing assignment of this entire linkage group. Five of the markers--DRD1L, PF4, ALB, AFP, and BSP--have been physically mapped to a large region of human Chr 4 encompassing the p arm and the q arm to band q28. Homologs of two of the markers, ALB and AFP, have been mapped to Chr 5 in the mouse. Comparison of human Chr 4 with the homologous regions on Chr 14 of the rat and Chr 5 of the mouse indicated that linkage conservation with human Chr 4 extends over a greater region in the rat than in the mouse. The markers described here were found to be highly polymorphic in twelve inbred strains (F344/N, LEW/N, ACI/N, BUF/N, BN/SsN, LOU/MN, MNR/N, MR/N, SHR/N, WBB1/N, WBB2/N, and WKY/N). These polymorphic markers should be useful in genetic linkage studies of important phenotypes in rats.

Citing Articles

A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.

Yamada J, Kuramoto T, Serikawa T Mamm Genome. 1994; 5(2):63-83.

PMID: 8180477 PMC: 7087631. DOI: 10.1007/BF00292332.

Linkage map of seven polymorphic markers on rat chromosome 18.

Remmers E, Goldmuntz E, Zha H, Crofford L, Cash J, Mathern P Mamm Genome. 1993; 4(5):265-70.

PMID: 8099512 DOI: 10.1007/BF00417433.

Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5.

Goldmuntz E, Remmers E, Zha H, Mathern P, Du Y, Crofford L Mamm Genome. 1993; 4(11):670-5.

PMID: 7904197 DOI: 10.1007/BF00360905.

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