Midsagittal MR Measurements of the Corpus Callosum in Healthy Subjects and Diseased Patients: a Prospective Survey

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 1993 Jan 1

PMID 8427077

Citations 13

Authors

J P Laissy

B Patrux

C DUCHATEAU

D Hannequin

P Hugonet

J Thiebot

Affiliations

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Abstract

Purpose: To determine quantitatively a possible corpus callosum (CC) involvement in normal aging and white matter diseases.

Methods: Midsagittal size and signal of CC were recorded prospectively from 243 routine MR brain examinations. A midline internal skull surface (MISS) and subcutaneous fat signal intensity were measured to calculate CC/MISS and CC/fat ratios. Four groups of subjects were studied: 124 apparently healthy subjects, 45 patients with multiple sclerosis, 13 patients with a noncerebral cancer under chemotherapy, and 37 AIDS patients.

Results: Mean surface area of CC in controls was 6.36 cm2. It was significantly larger in men than in women (P < .05), but CC/MISS ratio was not. Elderly controls > 70 years and AIDS patients displayed significant CC atrophy, as well as multiple sclerosis subjects with long-standing disease or with a severe chronic progressive form.

Conclusion: CC substance loss identification should not be based on visual inspection or on absolute area, but by means of a CC/MISS ratio.

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