Increasing Rates of DNA Single-strand Breaks in Lymphocytes of Clinical Personnel Handling Cytostatic Drugs

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 1993 Jan 1

PMID 8423200

Authors

M Reitz

S Afghanyar

P Gutjahr

Affiliations

Soon will be listed here.

Abstract

A total of 27 persons, working in cancer stations with exposure to cytostatics, and 40 healthy control persons were examined for DNA single-strand breaks in peripheral lymphocytes. Non-smoking personnel from cancer stations were found to have an increased rate of DNA single-strand breaks compared to the non-smoking control subjects. In the case of smokers an increased rate of DNA single-strand breaks could be recorded for those working in cancer stations as well as with the controls. DNA single-strand breaks indicate reversible damage to DNA. As DNA repair is not perfect in every case, an increased number of DNA single-strand breaks leads to irreversible DNA damage.

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