Polymorphism in the Upstream Regulatory Regions of HLA-DRB Genes

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1993 Jan 1

PMID 8423054

Citations 3

Authors

D P Singal

X Qiu

M DSouza

S K Sood

Affiliations

Soon will be listed here.

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References

Andersson G, Larhammar D, Widmark E, Servenius B, Peterson P, Rask L . Class II genes of the human major histocompatibility complex. Organization and evolutionary relationship of the DR beta genes. J Biol Chem. 1987; 262(18):8748-58. View

Yang Z, Sugawara M, Ponath P, Wessendorf L, Banerji J, Li Y . Interferon gamma response region in the promoter of the human DPA gene. Proc Natl Acad Sci U S A. 1990; 87(23):9226-30. PMC: 55137. DOI: 10.1073/pnas.87.23.9226. View

Bodmer J, Marsh S, Albert E, Bodmer W, DuPont B, Erlich H . Nomenclature for factors of the HLA system, 1990. Hum Immunol. 1991; 31(3):186-94. DOI: 10.1016/0198-8859(91)90025-5. View

Miwa K, Doyle C, Strominger J . Sequence-specific interactions of nuclear factors with conserved sequences of human class II major histocompatibility complex genes. Proc Natl Acad Sci U S A. 1987; 84(14):4939-43. PMC: 305222. DOI: 10.1073/pnas.84.14.4939. View

Didier D, Woulfe S, Schwartz B . Characterization of a DNA-binding protein system which is inversely correlated with class II expression. Immunol Res. 1990; 9(1):69-76. DOI: 10.1007/BF02918480. View

Sakurai M, Strominger J . B-cell-specific enhancer activity of conserved upstream elements of the class II major histocompatibility complex DQB gene. Proc Natl Acad Sci U S A. 1988; 85(18):6909-13. PMC: 282088. DOI: 10.1073/pnas.85.18.6909. View

Sodoyer R, Damotte M, Delovitch T, Trucy J, Jordan B, Strachan T . Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-CW3). EMBO J. 1984; 3(4):879-85. PMC: 557442. DOI: 10.1002/j.1460-2075.1984.tb01900.x. View

Kappes D, Strominger J . Human class II major histocompatibility complex genes and proteins. Annu Rev Biochem. 1988; 57:991-1028. DOI: 10.1146/annurev.bi.57.070188.005015. View

Peterlin B, Andersson G, Lotscher E, Tsang S . Transcriptional regulation of HLA class-II genes. Immunol Res. 1990; 9(3):164-77. DOI: 10.1007/BF02918176. View

10.

Hume C, Lee J . Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro. Tissue Antigens. 1990; 36(3):108-15. DOI: 10.1111/j.1399-0039.1990.tb01810.x. View

11.

Turco E, Manfras B, Ge L, Rudert W, Trucco M . The X boxes from promoters of HLA class II B genes at different loci do not complete for nuclear protein-specific binding. Immunogenetics. 1990; 32(2):117-28. DOI: 10.1007/BF00210449. View

12.

Cogswell J, Basta P, Ting J . X-box-binding proteins positively and negatively regulate transcription of the HLA-DRA gene through interaction with discrete upstream W and V elements. Proc Natl Acad Sci U S A. 1990; 87(19):7703-7. PMC: 54816. DOI: 10.1073/pnas.87.19.7703. View

13.

ANDERSEN L, Beaty J, Nettles J, Seyfried C, Nepom G, Nepoom B . Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes. J Exp Med. 1991; 173(1):181-92. PMC: 2118753. DOI: 10.1084/jem.173.1.181. View

14.

Tibensky D, Delovitch T . Promoter region of HLA-C genes: regulatory elements common to and different from those of HLA-A and HLA-B genes. Immunogenetics. 1990; 32(3):210-3. DOI: 10.1007/BF02114976. View

15.

Boothby M, Liou H, Glimcher L . Differences in DNA sequence specificity among MHC class II X box binding proteins. J Immunol. 1989; 142(3):1005-14. View

16.

Sherman P, Basta P, Ting J . Upstream DNA sequences required for tissue-specific expression of the HLA-DR alpha gene. Proc Natl Acad Sci U S A. 1987; 84(12):4254-8. PMC: 305063. DOI: 10.1073/pnas.84.12.4254. View

17.

SANGER F, Coulson A . A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol. 1975; 94(3):441-8. DOI: 10.1016/0022-2836(75)90213-2. View