Specific T-cell Recognition of the Merozoite Proteins Rhoptry-associated Protein 1 and Erythrocyte-binding Antigen 1 of Plasmodium Falciparum

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1993 Jan 1

PMID 8418048

Citations 12

Authors

P H Jakobsen

L Hviid

T G Theander

E A Afare

R G Ridley

P M Heegaard

D Stuber

K Dalsgaard

F K Nkrumah

Affiliations

Soon will be listed here.

Abstract

The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides.

Citing Articles

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