Cervical Neuroblastoma in Eleven Infants--a Tumor with Favorable Prognosis. Clinical and Radiologic (US, CT, MRI) Findings

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 1993 Jan 1

PMID 8414748

Citations 8

Authors

S J Abramson

W E Berdon

C Ruzal-Shapiro

C Stolar

J Garvin

Affiliations

Soon will be listed here.

Abstract

Cervical neuroblastoma, a disease primarily of infants, has a favorable prognosis. Eleven patients are reported. Clinical presentations (other than mass) included stridor and swallowing problems. Masses when felt were commonly mistaken for infectious adenitis. Imaging studies (US, CT, MRI) showed solid masses with vascular displacement and narrowing; intraspinal extension was absent though extension into the adjacent sites of mediastinum and skull occurred. Horner syndrome was seen in five patients with accompanying heterochromia iridis in one. Five tumors had calcification. A high index of suspicion will lead to biopsy and less delay in diagnosis once a mass is felt or imaged.

Citing Articles

Posttreatment complications in pediatric cervical neuroblastoma: A retrospective case series at a tertiary cancer center.

Lopez J, Subramanian T, Durell J, Levyn H, Wong R, Shah J J Surg Oncol. 2023; 129(2):219-223.

PMID: 37850570 PMC: 11637323. DOI: 10.1002/jso.27482.

Importance of Imaging in Congenital Unilateral Vocal Fold Paralysis: A Case of Neck Neuroblastoma Presenting with Unilateral Vocal Fold Paralysis.

Yeo W, Chan C, Tan K Case Rep Otolaryngol. 2021; 2021:7368567.

PMID: 34912584 PMC: 8668306. DOI: 10.1155/2021/7368567.

Radiogenomics of neuroblastomas: Relationships between imaging phenotypes, tumor genomic profile and survival.

Brisse H, Blanc T, Schleiermacher G, Mosseri V, Philippe-Chomette P, Janoueix-Lerosey I PLoS One. 2017; 12(9):e0185190.

PMID: 28945781 PMC: 5612658. DOI: 10.1371/journal.pone.0185190.

Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project.

Vo K, Matthay K, Neuhaus J, London W, Hero B, Ambros P J Clin Oncol. 2014; 32(28):3169-76.

PMID: 25154816 PMC: 4171360. DOI: 10.1200/JCO.2014.56.1621.

Cervical neuroblastoma.

Singh H, Mohan C, Mohindroo N, Sharma D Indian J Otolaryngol Head Neck Surg. 2012; 59(3):288-90.

PMID: 23120455 PMC: 3452113. DOI: 10.1007/s12070-007-0083-5.

References

Casselman J, Smet M, Van Damme B, LEMAHIEU S . Primary cervical neuroblastoma: CT and MR findings. J Comput Assist Tomogr. 1988; 12(4):684-6. DOI: 10.1097/00004728-198807000-00038. View

Cushing B, Slovis T, PHILIPPART A, Das L, Watts Jr F, CORBETT D . A rational approach to cervical neuroblastoma. Cancer. 1982; 50(4):785-7. DOI: 10.1002/1097-0142(19820815)50:4<785::aid-cncr2820500427>3.0.co;2-p. View

Smith M, Smith R, Bailey C . Primary cervical neuroblastoma in infants. J Laryngol Otol. 1985; 99(2):209-14. DOI: 10.1017/s0022215100096560. View

Plantaz D, Hartmann O, Kalifa C, Sainte-Rose C, Passagia J, Lemerle J . [Dumbbell neuroblastoma. Experience at the Gustave Roussy Institute in 38 cases treated from 1982 to 1987]. Arch Fr Pediatr. 1991; 48(8):529-33. View

Al-Jassim A . Cervical ganglioneuroblastoma. J Laryngol Otol. 1987; 101(3):296-301. DOI: 10.1017/s0022215100101677. View

McRae Jr D, Shaw A . Ganglioneuroma, heterochromia iridis, and Horner's syndrome. J Pediatr Surg. 1979; 14(5):612-4. DOI: 10.1016/s0022-3468(79)80152-9. View

Riggs Jr W, Benton C, Wood B . Cervical neurogenic tumors presenting as thoracic apical masses in infants and children. Pediatr Radiol. 1977; 5(4):201-3. DOI: 10.1007/BF00972176. View

Baker M, Kirks D, Korobkin M, Bowie J, Filston H . The association of neuroblastoma and myoclonic encephalopathy: an imaging approach. Pediatr Radiol. 1985; 15(3):184-90. DOI: 10.1007/BF02388608. View

Gibbs J, Appleton R, Martin J, Findlay G . Congenital Horner syndrome associated with non-cervical neuroblastoma. Dev Med Child Neurol. 1992; 34(7):642-4. DOI: 10.1111/j.1469-8749.1992.tb11495.x. View

10.

Jaffe N, Cassady R, Petersen R, Traggis D . Heterochromia and Horner syndrome associated with cervical and mediastinal neuroblastoma. J Pediatr. 1975; 87(1):75-7. DOI: 10.1016/s0022-3476(75)80072-2. View

11.

COLLIN P, Schmidt M, Bensoussan A, Blanchard H, DESJARDINS J . Neurogenic tumors and VIP-induced diarrhea. J Pediatr Surg. 1979; 14(5):525-6. DOI: 10.1016/s0022-3468(79)80130-x. View

12.

Musarella M, Chan H, DeBoer G, Gallie B . Ocular involvement in neuroblastoma: prognostic implications. Ophthalmology. 1984; 91(8):936-40. DOI: 10.1016/s0161-6420(84)34211-7. View

13.

Carlsen N, Schroeder H, Bro P, Erichsen G, Jensen K, Nielsen O . Neuroblastomas treated at the four major child oncologic clinics in Denmark 1943-1980: an evaluation of 180 cases. Med Pediatr Oncol. 1985; 13(4):180-6. DOI: 10.1002/mpo.2950130404. View

14.

Matthay K, Sather H, Seeger R, Haase G, Hammond G . Excellent outcome of stage II neuroblastoma is independent of residual disease and radiation therapy. J Clin Oncol. 1989; 7(2):236-44. DOI: 10.1200/JCO.1989.7.2.236. View

15.

Orr J . Cervical neuroblastoma in childhood--a better prognosis?. Clin Oncol. 1978; 4(4):353-8. View

16.

Ogita S, Tokiwa K, Takahashi T, Imashuku S, Sawada T . Congenital cervical neuroblastoma associated with Horner syndrome. J Pediatr Surg. 1988; 23(11):991-2. DOI: 10.1016/s0022-3468(88)80001-0. View