Role of Acid Tolerance Response Genes in Salmonella Typhimurium Virulence

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1993 Oct 1

PMID 8406841

Citations 31

Authors

F Garcia-del Portillo

J W FOSTER

B B Finlay

Affiliations

Soon will be listed here.

Abstract

The atp and fur genes are involved in the acid tolerance response of Salmonella typhimurium. An atp::Tn10 mutant was avirulent in the mouse typhoid model when assayed by oral and intraperitoneal routes. However, a fur mutant was completely virulent by the intraperitoneal route. No relevant differences in intracellular survival or invasion rates were observed for the two mutants in macrophages and epithelial cells. These data indicate that separate acid tolerance response genes may have different roles in S. typhimurium virulence.

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