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Plasma Concentrations of Bupivacaine After Wound Infiltration of an 0.5% Solution After Inguinal Herniorrhaphy: a Preliminary Study

Overview
Journal Eur J Clin Pharmacol
Specialty Pharmacology
Date 1993 Jan 1
PMID 8405012
Citations 7
Authors
H Kastrissios
E J Triggs
F Sinclair
P Moran
M Smithers
Affiliations
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Abstract

After routine inguinal herniorrhaphy we gave 12 patients a wound infiltration regimen of bolus doses of 20 ml of 0.5% bupivacaine via a catheter within the wound and rectally administered indomethacin (100 mg). Peak venous plasma bupivacaine concentrations ranged from 0.07 mg.l-1 to 1.14 mg.l-1 (mean (SD) 0.47 (0.33) mg.l-1), and occurred at between 0.25 and 2 h after the first dose. Plasma concentrations were well below the toxic threshold of 4 mg.l-1 and there was no accumulation. The regimen provided satisfactory analgesia. There were no wound infections nor signs of toxicity.

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