Rosenthal Fibers Producing a Granular Cell Appearance in a Glioblastoma

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1993 Jan 1

PMID 8396834

Citations 1

Authors

M R Del Bigio

J H Deck

Affiliations

Soon will be listed here.

Abstract

In this report we describe a glioblastoma multiforme with focal granular cell change. In most astroglial tumors with granular cells, the granular appearance is due to the presence of periodic acid-Schiff-positive, membrane-bound cellular debris. In the present case the granular appearance was due to the presence of many small Rosenthal fibers, which were immunoreactive for glial fibrillary acidic protein, vimentin, ubiquitin, and heat-shock protein 27, but not for alpha-B crystallin. The ultrastructural characteristics are described. These findings demonstrate that granulofilamentous inclusions with the appearance of Rosenthal fibers in glial tumors are a structurally heterogeneous feature.

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