Human FLT3/FLK2 Gene: CDNA Cloning and Expression in Hematopoietic Cells

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 1993 Aug 15

PMID 8394751

Citations 61

Authors

O Rosnet

C Schiff

M J Pebusque

S Marchetto

C Tonnelle

Y Toiron

F Birg

D Birnbaum

Affiliations

Soon will be listed here.

Abstract

The human FLT3 cDNA was cloned from a pre-B cell line and characterized. The deduced amino acid sequence shows that FLT3 codes for a receptor-type tyrosine kinase of 993 residues, presenting a strong similarity with the corresponding mouse FLT3/FLK2 protein as well as with the receptors for colony-stimulating factor 1 (CSF1R/FMS) and steel locus factor (SLFR/KIT). An analysis of the expression of the gene using amplification of reverse transcribed FLT3 mRNA by polymerase chain reaction shows that FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin.

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