"Diversomers": an Approach to Nonpeptide, Nonoligomeric Chemical Diversity

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1993 Aug 1

PMID 8394002

Citations 35

Authors

S H DEWITT

J S Kiely

C J Stankovic

M C Schroeder

D M Cody

M R Pavia

Affiliations

Soon will be listed here.

Abstract

Solid-phase chemistry, organic synthesis, and an apparatus for multiple, simultaneous synthesis have been combined to generate libraries of organic compounds ("diversomers"). Arrays of compounds were synthesized over two to three steps incorporating chemically diverse building blocks on a polystyrene-based solid support in a multiple, simultaneous manner. The generality of this approach is illustrated by the syntheses of dipeptides, hydantoins, and benzodiazepines.

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